• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

The BioGRID Interaction Database: 2011 update.

The Biological General Repository for Interaction Datasets (BioGRID) is a public database that archives and disseminates genetic and protein interaction data from model organisms and humans (http://www.thebiogrid.org). BioGRID currently holds 347,966 interactions (170,162 genetic, 177,804 protein) curated from both high-throughput data sets and individual focused studies, as derived from over 23,000 publications in the primary literature. Complete coverage of the entire literature is maintained for budding yeast (Saccharomyces cerevisiae), fission yeast (Schizosaccharomyces pombe) and thale cress (Arabidopsis thaliana), and efforts to expand curation across multiple metazoan species are underway. The BioGRID houses 48,831 human protein interactions that have been curated from 10,247 publications. Current curation drives are focused on particular areas of biology to enable insights into conserved networks and pathways that are relevant to human health. The BioGRID 3.0 web interface contains new search and display features that enable rapid queries across multiple data types and sources. An automated Interaction Management System (IMS) is used to prioritize, coordinate and track curation across international sites and projects. BioGRID provides interaction data to several model organism databases, resources such as Entrez-Gene and other interaction meta-databases. The entire BioGRID 3.0 data collection may be downloaded in multiple file formats, including PSI MI XML. Source code for BioGRID 3.0 is freely available without any restrictions.

Pubmed ID: 21071413

Authors

  • Stark C
  • Breitkreutz BJ
  • Chatr-Aryamontri A
  • Boucher L
  • Oughtred R
  • Livstone MS
  • Nixon J
  • Van Auken K
  • Wang X
  • Shi X
  • Reguly T
  • Rust JM
  • Winter A
  • Dolinski K
  • Tyers M

Journal

Nucleic acids research

Publication Data

January 23, 2011

Associated Grants

  • Agency: NCRR NIH HHS, Id: 1R01RR024031
  • Agency: Biotechnology and Biological Sciences Research Council, Id: BB/F010486/1
  • Agency: Canadian Institutes of Health Research, Id: FRN 82940
  • Agency: NHGRI NIH HHS, Id: P41-HG02223
  • Agency: NIH HHS, Id: R01 OD010929

Mesh Terms

  • Animals
  • Arabidopsis
  • Databases, Genetic
  • Gene Regulatory Networks
  • Humans
  • Protein Interaction Mapping
  • Saccharomyces cerevisiae
  • Schizosaccharomyces
  • User-Computer Interface