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The sequence read archive.

The combination of significantly lower cost and increased speed of sequencing has resulted in an explosive growth of data submitted into the primary next-generation sequence data archive, the Sequence Read Archive (SRA). The preservation of experimental data is an important part of the scientific record, and increasing numbers of journals and funding agencies require that next-generation sequence data are deposited into the SRA. The SRA was established as a public repository for the next-generation sequence data and is operated by the International Nucleotide Sequence Database Collaboration (INSDC). INSDC partners include the National Center for Biotechnology Information (NCBI), the European Bioinformatics Institute (EBI) and the DNA Data Bank of Japan (DDBJ). The SRA is accessible at from NCBI, at from EBI and at from DDBJ. In this article, we present the content and structure of the SRA, detail our support for sequencing platforms and provide recommended data submission levels and formats. We also briefly outline our response to the challenge of data growth.

Pubmed ID: 21062823


  • Leinonen R
  • Sugawara H
  • Shumway M
  • International Nucleotide Sequence Database Collaboration


Nucleic acids research

Publication Data

January 23, 2011

Associated Grants

  • Agency: Wellcome Trust, Id: 085532
  • Agency: Intramural NIH HHS, Id:
  • Agency: Wellcome Trust, Id:

Mesh Terms

  • Databases, Nucleic Acid
  • High-Throughput Nucleotide Sequencing