The mechanisms that regulate the activity of the nonreceptor tyrosine kinase Ack1 (activated Cdc42-associated kinase) are poorly understood. The amino-terminal region of Ack1 is predicted to contain a sterile alpha motif (SAM) domain. SAM domains share a common fold and mediate protein-protein interactions in a wide variety of proteins. Here, we addressed the importance of the Ack1 SAM domain in kinase activity.
Pubmed ID: 20979614 RIS Download
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View all literature mentionsCompact confocal microscope with highly sensitive GaAsP detection and fast linear scanning. The airyscan system allows capture images with high sensitivity and superresolution compared with conventional confocal microscope.
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