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Epigenetic inactivation of the NORE1 gene correlates with malignant progression of colorectal tumors.

BMC cancer | 2010

NORE1 (RASSF5) is a newly described member of the RASSF family with Ras effector function. NORE1 expression is frequently inactivated by aberrant promoter hypermethylation in many human cancers, suggesting that NORE1 might be a putative tumor suppressor. However, expression and mutation status of NORE1 and its implication in colorectal tumorigenesis has not been evaluated.

Pubmed ID: 20969767 RIS Download

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