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Characteristics of adolescents and youth with recent-onset type 2 diabetes: the TODAY cohort at baseline.

CONTEXT: The Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) cohort represents the largest and best-characterized national sample of American youth with recent-onset type 2 diabetes. OBJECTIVE: The objective of the study was to describe the baseline characteristics of participants in the TODAY randomized clinical trial. DESIGN: Participants were recruited over 4 yr at 15 clinical centers in the United States (n = 704) and enrolled, randomized, treated, and followed up 2-6 yr. SETTING: The study was conducted at pediatric diabetes care clinics and practices. PARTICIPANTS: Eligible participants were aged 10-17 yr inclusive, diagnosed with type 2 diabetes for less than 2 yr and had a body mass index at the 85th percentile or greater. INTERVENTIONS: After baseline data collection, participants were randomized to one of the following groups: 1) metformin alone, 2) metformin plus rosiglitazone, or 3) metformin plus a lifestyle program of weight management. MAIN OUTCOME MEASURES: Baseline data presented include demographics, clinical/medical history, biochemical measurements, and clinical and biochemical abnormalities. RESULTS: At baseline the cohort included the following: 64.9% were female; mean age was 14.0 yr; mean diabetes duration was 7.8 months; mean body mass index Z-score was 2.15; 89.4% had a family history of diabetes; 41.1% were Hispanic, 31.5% were non-Hispanic black; 38.8% were living with both biological parents; 41.5% had a household annual income of less than $25,000; 26.3% had a highest education level of parent/guardian less than a high school degree; 26.3% had a blood pressure at the 90th percentile or greater; 13.6% had a blood pressure at the 95th percentile or greater; 13.0% had microalbuminuria; 79.8% had a low high-density lipoprotein level; and 10.2% had high triglycerides. CONCLUSIONS: The TODAY cohort is predominantly from racial/ethnic minority groups, with low socioeconomic status and a family history of diabetes. Clinical and biochemical abnormalities and comorbidities are prevalent within 2 yr of diagnosis. These findings contribute greatly to our understanding of American youth with type 2 diabetes.

Pubmed ID: 20962021

Authors

  • Copeland KC
  • Zeitler P
  • Geffner M
  • Guandalini C
  • Higgins J
  • Hirst K
  • Kaufman FR
  • Linder B
  • Marcovina S
  • McGuigan P
  • Pyle L
  • Tamborlane W
  • Willi S
  • TODAY Study Group

Journal

The Journal of clinical endocrinology and metabolism

Publication Data

January 6, 2011

Associated Grants

  • Agency: NCRR NIH HHS, Id: M01-RR00036
  • Agency: NCRR NIH HHS, Id: M01-RR00043-45
  • Agency: NCRR NIH HHS, Id: M01-RR00069
  • Agency: NCRR NIH HHS, Id: M01-RR00084
  • Agency: NCRR NIH HHS, Id: M01-RR00125
  • Agency: NCRR NIH HHS, Id: M01-RR01066
  • Agency: NCRR NIH HHS, Id: M01-RR14467
  • Agency: NIDDK NIH HHS, Id: U01 DK061230
  • Agency: NIDDK NIH HHS, Id: U01 DK061230-10
  • Agency: NIDDK NIH HHS, Id: U01-DK61212
  • Agency: NIDDK NIH HHS, Id: U01-DK61230
  • Agency: NIDDK NIH HHS, Id: U01-DK61239
  • Agency: NIDDK NIH HHS, Id: U01-DK61242
  • Agency: NIDDK NIH HHS, Id: U01-DK61254
  • Agency: NCRR NIH HHS, Id: UL1 RR024992
  • Agency: NCRR NIH HHS, Id: UL1 RR025758
  • Agency: NCRR NIH HHS, Id: UL1-RR024134
  • Agency: NCRR NIH HHS, Id: UL1-RR024139
  • Agency: NCRR NIH HHS, Id: UL1-RR024153
  • Agency: NCRR NIH HHS, Id: UL1-RR024989
  • Agency: NCRR NIH HHS, Id: UL1-RR024992
  • Agency: NCRR NIH HHS, Id: UL1-RR025758
  • Agency: NCRR NIH HHS, Id: UL1-RR025780

Mesh Terms

  • Adolescent
  • Blood Glucose
  • Body Mass Index
  • Child
  • Cohort Studies
  • Diabetes Mellitus, Type 2
  • Female
  • Humans
  • Insulin
  • Lipids
  • Male
  • Obesity
  • Physical Examination
  • Quality of Life