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T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.

The molecular events underlying the progression of T-lymphoblastic lymphoma (T-LBL) to acute T-lymphoblastic leukemia (T-ALL) remain elusive. In our zebrafish model, concomitant overexpression of bcl-2 with Myc accelerated T-LBL onset while inhibiting progression to T-ALL. The T-LBL cells failed to invade the vasculature and showed evidence of increased homotypic cell-cell adhesion and autophagy. Further analysis using clinical biopsy specimens revealed autophagy and increased levels of BCL2, S1P1, and ICAM1 in human T-LBL compared with T-ALL. Inhibition of S1P1 signaling in T-LBL cells led to decreased homotypic adhesion in vitro and increased tumor cell intravasation in vivo. Thus, blockade of intravasation and hematologic dissemination in T-LBL is due to elevated S1P1 signaling, increased expression of ICAM1, and augmented homotypic cell-cell adhesion.

Pubmed ID: 20951945

Authors

  • Feng H
  • Stachura DL
  • White RM
  • Gutierrez A
  • Zhang L
  • Sanda T
  • Jette CA
  • Testa JR
  • Neuberg DS
  • Langenau DM
  • Kutok JL
  • Zon LI
  • Traver D
  • Fleming MD
  • Kanki JP
  • Look AT

Journal

Cancer cell

Publication Data

October 19, 2010

Associated Grants

  • Agency: NIDDK NIH HHS, Id: 1K01DK074555
  • Agency: NCI NIH HHS, Id: 1K08CA133103
  • Agency: NIAMS NIH HHS, Id: 3K01AR055619-03S1
  • Agency: NCI NIH HHS, Id: CA068484
  • Agency: NCI NIH HHS, Id: CA077429
  • Agency: NIAMS NIH HHS, Id: K01 AR055619
  • Agency: NIAMS NIH HHS, Id: K01AR05562190-01A1
  • Agency: NCI NIH HHS, Id: K08 CA133103
  • Agency: NCI NIH HHS, Id: K08 CA133103-01
  • Agency: NCI NIH HHS, Id: K08 CA133103-02
  • Agency: NCI NIH HHS, Id: K08 CA133103-03
  • Agency: NCI NIH HHS, Id: K08 CA133103-04
  • Agency: NCI NIH HHS, Id: K99 CA134743
  • Agency: NCI NIH HHS, Id: K99CA134743
  • Agency: NCI NIH HHS, Id: L40 CA124083
  • Agency: NCI NIH HHS, Id: L40 CA124083-01
  • Agency: NCI NIH HHS, Id: L40 CA124083-02
  • Agency: NCI NIH HHS, Id: R00 CA134743
  • Agency: NCI NIH HHS, Id: R01 CA077429
  • Agency: NHLBI NIH HHS, Id: T32-HL086344

Mesh Terms

  • Animals
  • Animals, Genetically Modified
  • Autophagy
  • Blood Vessels
  • Cell Aggregation
  • Cell Line, Tumor
  • Cell Movement
  • Disease Progression
  • Enzyme Activation
  • Gene Expression Regulation, Leukemic
  • Humans
  • Immunohistochemistry
  • Intercellular Adhesion Molecule-1
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
  • Proto-Oncogene Proteins c-akt
  • Proto-Oncogene Proteins c-bcl-2
  • Proto-Oncogene Proteins c-myc
  • Receptors, Lysosphingolipid
  • Zebrafish