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T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.

Cancer cell | Oct 19, 2010

http://www.ncbi.nlm.nih.gov/pubmed/20951945

The molecular events underlying the progression of T-lymphoblastic lymphoma (T-LBL) to acute T-lymphoblastic leukemia (T-ALL) remain elusive. In our zebrafish model, concomitant overexpression of bcl-2 with Myc accelerated T-LBL onset while inhibiting progression to T-ALL. The T-LBL cells failed to invade the vasculature and showed evidence of increased homotypic cell-cell adhesion and autophagy. Further analysis using clinical biopsy specimens revealed autophagy and increased levels of BCL2, S1P1, and ICAM1 in human T-LBL compared with T-ALL. Inhibition of S1P1 signaling in T-LBL cells led to decreased homotypic adhesion in vitro and increased tumor cell intravasation in vivo. Thus, blockade of intravasation and hematologic dissemination in T-LBL is due to elevated S1P1 signaling, increased expression of ICAM1, and augmented homotypic cell-cell adhesion.

Pubmed ID: 20951945 RIS Download

Mesh terms: Animals | Animals, Genetically Modified | Autophagy | Blood Vessels | Cell Aggregation | Cell Line, Tumor | Cell Movement | Disease Progression | Enzyme Activation | Gene Expression Regulation, Leukemic | Humans | Immunohistochemistry | Intercellular Adhesion Molecule-1 | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | Proto-Oncogene Proteins c-akt | Proto-Oncogene Proteins c-bcl-2 | Proto-Oncogene Proteins c-myc | Receptors, Lysosphingolipid | Zebrafish

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Associated grants

  • Agency: NIDDK NIH HHS, Id: 1K01DK074555
  • Agency: NCI NIH HHS, Id: 1K08CA133103
  • Agency: NIAMS NIH HHS, Id: 3K01AR055619-03S1
  • Agency: NCI NIH HHS, Id: CA068484
  • Agency: NCI NIH HHS, Id: CA077429
  • Agency: NIAMS NIH HHS, Id: K01 AR055619
  • Agency: NIAMS NIH HHS, Id: K01AR05562190-01A1
  • Agency: NCI NIH HHS, Id: K08 CA133103
  • Agency: NCI NIH HHS, Id: K08 CA133103-01
  • Agency: NCI NIH HHS, Id: K08 CA133103-02
  • Agency: NCI NIH HHS, Id: K08 CA133103-03
  • Agency: NCI NIH HHS, Id: K08 CA133103-04
  • Agency: NCI NIH HHS, Id: K99 CA134743
  • Agency: NCI NIH HHS, Id: K99CA134743
  • Agency: NCI NIH HHS, Id: L40 CA124083
  • Agency: NCI NIH HHS, Id: L40 CA124083-01
  • Agency: NCI NIH HHS, Id: L40 CA124083-02
  • Agency: NCI NIH HHS, Id: R00 CA134743
  • Agency: NCI NIH HHS, Id: R01 CA077429
  • Agency: NHLBI NIH HHS, Id: T32-HL086344

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