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Functional redundancy of paralogs of an anaphase promoting complex/cyclosome subunit in Caenorhabditis elegans meiosis.

Genetics | Dec 15, 2010

http://www.ncbi.nlm.nih.gov/pubmed/20944012

The anaphase promoting complex/cyclosome (APC/C) mediates the metaphase-to-anaphase transition by instructing the ubiquitination and turnover of key proteins at this stage of the cell cycle. We have recovered a gain-of-function allele in an APC5 subunit of the anaphase promoting complex/cyclosome. This finding led us to investigate further the role of APC5 in Caenorhabditis elegans, which contains two APC5 paralogs. We have shown that these two paralogs, such-1 and gfi-3, are coexpressed in the germline but have nonoverlapping expression patterns in other tissues. Depletion of such-1 or gfi-3 alone does not have a notable effect on the meiotic divisions; however, codepletion of these two factors results in meiotic arrest. In sum, the two C. elegans APC5 paralogs have a redundant function during the meiotic divisions.

Pubmed ID: 20944012 RIS Download

Mesh terms: Alleles | Anaphase-Promoting Complex-Cyclosome | Animals | Caenorhabditis elegans | Caenorhabditis elegans Proteins | Gene Expression Regulation | Meiosis | Protein Subunits | Tissue Distribution | Ubiquitin-Protein Ligase Complexes