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KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching.

We show that knockdown of KLF1 in human and mouse adult erythroid progenitors markedly reduces BCL11A levels and increases human gamma-globin/beta-globin expression ratios. These results suggest that KLF1 controls globin gene switching by directly activating beta-globin and indirectly repressing gamma-globin gene expression. Controlled knockdown of KLF1 in adult erythroid progenitors may provide a method to activate fetal hemoglobin expression in individuals with beta-thalassemia or sickle cell disease.

Pubmed ID: 20676097


  • Zhou D
  • Liu K
  • Sun CW
  • Pawlik KM
  • Townes TM


Nature genetics

Publication Data

September 30, 2010

Associated Grants

  • Agency: NIDDK NIH HHS, Id: 1R01 DK073391
  • Agency: NIDDK NIH HHS, Id: R01 DK073391

Mesh Terms

  • Adult Stem Cells
  • Animals
  • Carrier Proteins
  • Cells, Cultured
  • Embryo, Mammalian
  • Erythropoiesis
  • Gene Expression Regulation, Developmental
  • Genes, Switch
  • Humans
  • Kruppel-Like Transcription Factors
  • Mice
  • Mice, Transgenic
  • Nuclear Proteins
  • beta-Globins
  • gamma-Globins