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KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching.

Nature genetics | Sep 30, 2010

http://www.ncbi.nlm.nih.gov/pubmed/20676097

We show that knockdown of KLF1 in human and mouse adult erythroid progenitors markedly reduces BCL11A levels and increases human gamma-globin/beta-globin expression ratios. These results suggest that KLF1 controls globin gene switching by directly activating beta-globin and indirectly repressing gamma-globin gene expression. Controlled knockdown of KLF1 in adult erythroid progenitors may provide a method to activate fetal hemoglobin expression in individuals with beta-thalassemia or sickle cell disease.

Pubmed ID: 20676097 RIS Download

Mesh terms: Adult Stem Cells | Animals | Carrier Proteins | Cells, Cultured | Embryo, Mammalian | Erythropoiesis | Gene Expression Regulation, Developmental | Genes, Switch | Humans | Kruppel-Like Transcription Factors | Mice | Mice, Transgenic | Nuclear Proteins | beta-Globins | gamma-Globins

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Associated grants

  • Agency: NIDDK NIH HHS, Id: 1R01 DK073391
  • Agency: NIDDK NIH HHS, Id: R01 DK073391

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