We have updated our privacy policy. If you have any question, contact us at privacy@scicrunch.org. Dismiss and don't show again

Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Negative regulation of hypoxic responses via induced Reptin methylation.

Molecular cell | Jul 9, 2010

Lysine methylation within histones is crucial for transcriptional regulation and thus links chromatin states to biological outcomes. Although recent studies have extended lysine methylation to nonhistone proteins, underlying molecular mechanisms such as the upstream signaling cascade that induces lysine methylation and downstream target genes modulated by this modification have not been elucidated. Here, we show that Reptin, a chromatin-remodeling factor, is methylated at lysine 67 in hypoxic conditions by the methyltransferase G9a. Methylated Reptin binds to the promoters of a subset of hypoxia-responsive genes and negatively regulates transcription of these genes to modulate cellular responses to hypoxia.

Pubmed ID: 20603076 RIS Download

Mesh terms: Animals | Carrier Proteins | Cell Hypoxia | Cell Line | DNA Helicases | Female | Gene Expression Regulation, Neoplastic | Histocompatibility Antigens | Histone-Lysine N-Methyltransferase | Humans | Hypoxia-Inducible Factor 1, alpha Subunit | Lysine | Methylation | Mice | Models, Biological | Neoplasms | Oligonucleotide Array Sequence Analysis | Promoter Regions, Genetic | Protein Binding | Xenograft Model Antitumor Assays

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

Associated grants

  • Agency: NIGMS NIH HHS, Id: R01 GM079641

BioGRID (Data, Interactions)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.