• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Interplay between Cdh1 and JNK activity during the cell cycle.

The ubiquitin ligase APC/C(Cdh1) coordinates degradation of key cell cycle regulators. We report here that a nuclear-localized portion of the stress-activated kinase JNK is degraded by the APC/C(Cdh1) during exit from mitosis and the G1 phase of the cell cycle. Expression of a non-degradable JNK induces prometaphase-like arrest and aberrant mitotic spindle dynamics. Moreover, JNK phosphorylates Cdh1 directly, during G2 and early mitosis, changing its subcellular localization and attenuating its ability to activate the APC/C during G2/M. This regulatory mechanism between JNK and Cdh1 reveals an important function for JNK during the cell cycle.

Pubmed ID: 20581839

Authors

  • Gutierrez GJ
  • Tsuji T
  • Chen M
  • Jiang W
  • Ronai ZA

Journal

Nature cell biology

Publication Data

July 2, 2010

Associated Grants

  • Agency: NCI NIH HHS, Id: CA78419
  • Agency: NCI NIH HHS, Id: P30 CA030199
  • Agency: NCI NIH HHS, Id: R01 CA138143
  • Agency: NCI NIH HHS, Id: R01 CA138143-02

Mesh Terms

  • Cadherins
  • Cell Cycle
  • Cell Line
  • Flow Cytometry
  • G1 Phase
  • HeLa Cells
  • Humans
  • Immunoprecipitation
  • MAP Kinase Kinase 4
  • Mitosis
  • Phosphorylation