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Interplay between Cdh1 and JNK activity during the cell cycle.

The ubiquitin ligase APC/C(Cdh1) coordinates degradation of key cell cycle regulators. We report here that a nuclear-localized portion of the stress-activated kinase JNK is degraded by the APC/C(Cdh1) during exit from mitosis and the G1 phase of the cell cycle. Expression of a non-degradable JNK induces prometaphase-like arrest and aberrant mitotic spindle dynamics. Moreover, JNK phosphorylates Cdh1 directly, during G2 and early mitosis, changing its subcellular localization and attenuating its ability to activate the APC/C during G2/M. This regulatory mechanism between JNK and Cdh1 reveals an important function for JNK during the cell cycle.

Pubmed ID: 20581839


  • Gutierrez GJ
  • Tsuji T
  • Chen M
  • Jiang W
  • Ronai ZA


Nature cell biology

Publication Data

July 2, 2010

Associated Grants

  • Agency: NCI NIH HHS, Id: CA78419
  • Agency: NCI NIH HHS, Id: P30 CA030199
  • Agency: NCI NIH HHS, Id: R01 CA138143
  • Agency: NCI NIH HHS, Id: R01 CA138143-02

Mesh Terms

  • Cadherins
  • Cell Cycle
  • Cell Line
  • Flow Cytometry
  • G1 Phase
  • HeLa Cells
  • Humans
  • Immunoprecipitation
  • MAP Kinase Kinase 4
  • Mitosis
  • Phosphorylation