Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells.

Cancer cell | Jun 15, 2010

We report a Jak2V617F knockin mouse myeloproliferative neoplasm (MPN) model resembling human polycythemia vera (PV). The MPN is serially transplantable and we demonstrate that the hematopoietic stem cell (HSC) compartment has the unique capacity for disease initiation but does not have a significant selective competitive advantage over wild-type HSCs. In contrast, myeloid progenitor populations are expanded and skewed toward the erythroid lineage, but cannot transplant the disease. Treatment with a JAK2 kinase inhibitor ameliorated the MPN phenotype, but did not eliminate the disease-initiating population. These findings provide insights into the consequences of JAK2 activation on HSC differentiation and function and have the potential to inform therapeutic approaches to JAK2V617F-positive MPN.

Pubmed ID: 20541703 RIS Download

Mesh terms: Amino Acid Substitution | Animals | Antigens, CD | Bone Marrow | Bone Marrow Cells | Bone Marrow Transplantation | Cell Count | Cell Differentiation | Disease Models, Animal | Erythroid Precursor Cells | Erythropoietin | Gene Expression | Gene Expression Profiling | Hematocrit | Hematopoietic Stem Cell Transplantation | Hematopoietic Stem Cells | Heterozygote | Humans | Janus Kinase 2 | Megakaryocyte Progenitor Cells | Megakaryocyte-Erythroid Progenitor Cells | Mice | Mice, Inbred C57BL | Mice, Transgenic | Myeloid Progenitor Cells | Myeloproliferative Disorders | Polycythemia Vera | Protein Kinase Inhibitors | Pyrrolidines | Spleen | Sulfonamides | Survival Analysis

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

Associated grants

  • Agency: NIDDK NIH HHS, Id: P30 DK049216
  • Agency: NCI NIH HHS, Id: P01 CA066996
  • Agency: NIDDK NIH HHS, Id: P30 DK49216
  • Agency: NHLBI NIH HHS, Id: T32HL0763
  • Agency: NHLBI NIH HHS, Id: R01 HL082945-04
  • Agency: NCI NIH HHS, Id: P01 CA 66996-11
  • Agency: NHLBI NIH HHS, Id: R01 HL082950

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.