We have updated our privacy policy. If you have any question, contact us at privacy@scicrunch.org. Dismiss and don't show again

Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

S100A4 regulates macrophage chemotaxis.

S100A4, a member of the S100 family of Ca(2+)-binding proteins, is directly involved in tumor metastasis. In addition to its expression in tumor cells, S100A4 is expressed in normal cells and tissues, including fibroblasts and cells of the immune system. To examine the contribution of S100A4 to normal physiology, we established S100A4-deficient mice by gene targeting. Homozygous S100A4(-/-) mice are fertile, grow normally and exhibit no overt abnormalities; however, the loss of S100A4 results in impaired recruitment of macrophages to sites of inflammation in vivo. Consistent with these observations, primary bone marrow macrophages (BMMs) derived from S100A4(-/-) mice display defects in chemotactic motility in vitro. S100A4(-/-) BMMs form unstable protrusions, overassemble myosin-IIA, and exhibit altered colony-stimulating factor-1 receptor signaling. These studies establish S100A4 as a regulator of physiological macrophage motility and demonstrate that S100A4 mediates macrophage recruitment and chemotaxis in vivo.

Pubmed ID: 20519440 RIS Download

Mesh terms: Actomyosin | Animals | Bone Marrow Cells | Cell Count | Cell Surface Extensions | Chemotaxis | Cytoskeleton | Heterocyclic Compounds, 4 or More Rings | Humans | Inflammation | Macrophage Colony-Stimulating Factor | Macrophages | Mice | Mice, Knockout | Models, Biological | Receptor, Macrophage Colony-Stimulating Factor | S100 Calcium-Binding Protein A4 | S100 Proteins | Signal Transduction

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIAID NIH HHS, Id: R56 AI007289
  • Agency: NIAID NIH HHS, Id: AI-07289
  • Agency: NIAID NIH HHS, Id: R01 AI007289
  • Agency: NCI NIH HHS, Id: CA-129598
  • Agency: NCI NIH HHS, Id: R01 CA129598

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.