Literature search services are currently unavailable. During our hosting provider's UPS upgrade we experienced a hardware failure and are currently working to resolve the issue.

Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

GWAMA: software for genome-wide association meta-analysis.

BACKGROUND: Despite the recent success of genome-wide association studies in identifying novel loci contributing effects to complex human traits, such as type 2 diabetes and obesity, much of the genetic component of variation in these phenotypes remains unexplained. One way to improving power to detect further novel loci is through meta-analysis of studies from the same population, increasing the sample size over any individual study. Although statistical software analysis packages incorporate routines for meta-analysis, they are ill equipped to meet the challenges of the scale and complexity of data generated in genome-wide association studies. RESULTS: We have developed flexible, open-source software for the meta-analysis of genome-wide association studies. The software incorporates a variety of error trapping facilities, and provides a range of meta-analysis summary statistics. The software is distributed with scripts that allow simple formatting of files containing the results of each association study and generate graphical summaries of genome-wide meta-analysis results. CONCLUSIONS: The GWAMA (Genome-Wide Association Meta-Analysis) software has been developed to perform meta-analysis of summary statistics generated from genome-wide association studies of dichotomous phenotypes or quantitative traits. Software with source files, documentation and example data files are freely available online at

Pubmed ID: 20509871


  • M├Ągi R
  • Morris AP


BMC bioinformatics

Publication Data

June 30, 2010

Associated Grants

  • Agency: Wellcome Trust, Id: 064890
  • Agency: Wellcome Trust, Id: 081682
  • Agency: Wellcome Trust, Id: WT081682/Z/06/Z

Mesh Terms

  • Databases, Genetic
  • Genome
  • Genome-Wide Association Study
  • Genotype
  • Phenotype
  • Software