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Association of race and ethnicity with withdrawal symptoms, attrition, opioid use, and side-effects during buprenorphine therapy.

Some studies report differences in opioid withdrawal between racial/ethnic groups. However, it is not known if these differences are reflected in differential treatment response. Data from National Institute on Drug Abuse (NIDA) Clinical Trials Network-003 were used to examine racial/ethnic differences before and during stabilization with buprenorphine. At induction, non-Hispanic Caucasians had higher objective and subjective withdrawal scores and greater opioid craving than minority participants. No significant between-group differences were observed on these scales following buprenorphine. Non-Hispanic Caucasians and Hispanics reported more adverse events than African Americans. Although ethnic and racial differences were observed prior to buprenorphine treatment, scores following buprenorphine treatment were similar between groups.

Pubmed ID: 20509084


  • Brown ES
  • Tirado C
  • Minhajuddin A
  • Hillhouse M
  • Adinoff B
  • Ling W
  • Doraimani G
  • Thomas C


Journal of ethnicity in substance abuse

Publication Data

May 28, 2010

Associated Grants

  • Agency: NIDA NIH HHS, Id: U10 DA013045
  • Agency: NIDA NIH HHS, Id: U10 DA020024
  • Agency: NIDA NIH HHS, Id: U10 DA020024-04

Mesh Terms

  • Adult
  • African Americans
  • Buprenorphine
  • European Continental Ancestry Group
  • Female
  • Hispanic Americans
  • Humans
  • Male
  • Middle Aged
  • Narcotic Antagonists
  • National Institute on Drug Abuse (U.S.)
  • Opioid-Related Disorders
  • Randomized Controlled Trials as Topic
  • Substance Withdrawal Syndrome
  • United States
  • Young Adult