Literature search services are currently unavailable. During our hosting provider's UPS upgrade we experienced a hardware failure and are currently working to resolve the issue.

Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

The Mohawk homeobox gene is a critical regulator of tendon differentiation.

Mohawk (Mkx) is a member of the Three Amino acid Loop Extension superclass of atypical homeobox genes that is expressed in developing tendons. To investigate the in vivo functions of Mkx, we generated Mkx(-/-) mice. These mice had hypoplastic tendons throughout the body. Despite the reduction in tendon mass, the cell number in tail tendon fiber bundles was similar between wild-type and Mkx(-/-) mice. We also observed small collagen fibril diameters and a down-regulation of type I collagen in Mkx(-/-) tendons. These data indicate that Mkx plays a critical role in tendon differentiation by regulating type I collagen production in tendon cells.

Pubmed ID: 20498044


  • Ito Y
  • Toriuchi N
  • Yoshitaka T
  • Ueno-Kudoh H
  • Sato T
  • Yokoyama S
  • Nishida K
  • Akimoto T
  • Takahashi M
  • Miyaki S
  • Asahara H


Proceedings of the National Academy of Sciences of the United States of America

Publication Data

June 8, 2010

Associated Grants


Mesh Terms

  • Animals
  • Cell Differentiation
  • Collagen Type I
  • Gene Expression Regulation, Developmental
  • Homeodomain Proteins
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Microscopy, Electron, Transmission
  • Tendons
  • Tensile Strength