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FIGLA, a basic helix-loop-helix transcription factor, balances sexually dimorphic gene expression in postnatal oocytes.

http://www.ncbi.nlm.nih.gov/pubmed/20479125

Maintenance of sex-specific germ cells requires balanced activation and repression of genetic hierarchies to ensure gender-appropriate development in mammals. Figla (factor in the germ line, alpha) encodes a germ cell-specific basic helix-loop-helix transcription factor first identified as an activator of oocyte genes. In comparing the ovarian proteome of normal and Figla null newborn mice, 18 testis-specific or -enhanced proteins were identified that were more abundant in Figla null ovaries than in normal ovaries. Transgenic mice, ectopically expressing Figla in male germ cells, downregulated a subset of these genes and demonstrated age-related sterility associated with impaired meiosis and germ cell apoptosis. Testis-associated genes, including Tdrd1, Tdrd6, and Tdrd7, were suppressed in the transgenic males with a corresponding disruption of the sperm chromatoid body and mislocalization of MVH and MILI proteins, previously implicated in posttranscriptional processing of RNA. These data demonstrate that physiological expression of Figla plays a critical dual role in activation of oocyte-associated genes and repression of sperm-associated genes during normal postnatal oogenesis.

Pubmed ID: 20479125 RIS Download

Mesh terms: Animals | Animals, Newborn | Basic Helix-Loop-Helix Transcription Factors | Fatty Acids | Fatty Alcohols | Female | Gene Expression | Male | Mice | Mice, Knockout | Mice, Transgenic | Oocytes | Oogenesis | Ovary | RNA, Messenger | Recombinant Proteins | Sex Characteristics | Testis

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Associated grants

  • Agency: Intramural NIH HHS, Id:

Mouse Genome Informatics (Data, Gene Annotation)

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