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Interactive effects of stress and aging on structural plasticity in the prefrontal cortex.

Neuronal networks in the prefrontal cortex mediate the highest levels of cognitive processing and decision making, and the capacity to perform these functions is among the cognitive features most vulnerable to aging. Despite much research, the neurobiological basis of age-related compromised prefrontal function remains elusive. Many investigators have hypothesized that exposure to stress may accelerate cognitive aging, though few studies have directly tested this hypothesis and even fewer have investigated a neuronal basis for such effects. It is known that in young animals, stress causes morphological remodeling of prefrontal pyramidal neurons that is reversible. The present studies sought to determine whether age influences the reversibility of stress-induced morphological plasticity in rat prefrontal neurons. We hypothesized that neocortical structural resilience is compromised in normal aging. To directly test this hypothesis we used a well characterized chronic restraint stress paradigm, with an additional group allowed to recover from the stress paradigm, in 3-, 12-, and 20-month-old male rats. In young animals, stress induced reductions of apical dendritic length and branch number, which were reversed with recovery; in contrast, middle-aged and aged rats failed to show reversible morphological remodeling when subjected to the same stress and recovery paradigm. The data presented here provide evidence that aging is accompanied by selective impairments in long-term neocortical morphological plasticity.

Pubmed ID: 20463234

Authors

  • Bloss EB
  • Janssen WG
  • McEwen BS
  • Morrison JH

Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience

Publication Data

May 12, 2010

Associated Grants

  • Agency: NIA NIH HHS, Id: 1F31AG034794-01A1
  • Agency: NIA NIH HHS, Id: F31 AG034794-02
  • Agency: NIMH NIH HHS, Id: MH58911
  • Agency: NIMH NIH HHS, Id: P50 MH058911
  • Agency: NIMH NIH HHS, Id: P50 MH058911-050003

Mesh Terms

  • Adrenal Glands
  • Aging
  • Animals
  • Body Weight
  • Chronic Disease
  • Dendrites
  • Disease Models, Animal
  • Male
  • Neuronal Plasticity
  • Neurons
  • Organ Size
  • Prefrontal Cortex
  • Rats
  • Rats, Sprague-Dawley
  • Stress, Psychological