We have updated our privacy policy. If you have any question, contact us at privacy@scicrunch.org. Dismiss and don't show again

Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation.

Cell | May 14, 2010

Extracellular signals regulate protein translation in many cell functions. A key advantage of control at the translational level is the opportunity to regulate protein synthesis within specific cellular subregions. However, little is known about mechanisms that may link extracellular cues to translation with spatial precision. Here, we show that a transmembrane receptor, DCC, forms a binding complex containing multiple translation components, including eukaryotic initiation factors, ribosomal large and small subunits, and monosomes. In neuronal axons and dendrites DCC colocalizes in particles with translation machinery, and newly synthesized protein. The extracellular ligand netrin promoted DCC-mediated translation and disassociation of translation components. The functional and physical association of a cell surface receptor with the translation machinery leads to a generalizable model for localization and extracellular regulation of protein synthesis, based on a transmembrane translation regulation complex.

Pubmed ID: 20434207 RIS Download

Mesh terms: Amino Acid Motifs | Animals | Axons | Cells, Cultured | Chick Embryo | Dendrites | Hippocampus | Humans | Mice | Nerve Growth Factors | Neurons | Protein Biosynthesis | Protein Structure, Tertiary | Rats | Receptors, Cell Surface | Ribosomal Proteins | Ribosomes | Tumor Suppressor Proteins

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NEI NIH HHS, Id: R01 EY011559-19
  • Agency: NICHD NIH HHS, Id: R37 HD029417-19
  • Agency: NICHD NIH HHS, Id: R37 HD029417
  • Agency: NINDS NIH HHS, Id: P01 NS040043
  • Agency: Canadian Institutes of Health Research, Id: P01 NS040043-100003
  • Agency: NINDS NIH HHS, Id: R01 EY011559
  • Agency: NEI NIH HHS, Id:

BioGRID (Data, Interactions)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.