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The coordinated p53 and estrogen receptor cis-regulation at an FLT1 promoter SNP is specific to genotoxic stress and estrogenic compound.

PloS one | 2010

Recently, we established that a C>T single nucleotide polymorphism (SNP) in the promoter of the VEGF receptor FLT1 gene generates a (1/2) site p53 response element (RE-T) that results in p53 responsiveness of the promoter. The transcriptional control required an estrogen receptor (ER) (1/2) site response element (ERE1) 225 nt upstream to the RE-T.

Pubmed ID: 20422012 RIS Download

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Associated grants

  • Agency: Intramural NIH HHS, United States
    Id: Z01 ES065079
  • Agency: NIEHS NIH HHS, United States
    Id: 1 Z01ES065079

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