• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Batf coordinates multiple aspects of B and T cell function required for normal antibody responses.

Batf belongs to the activator protein 1 superfamily of basic leucine zipper transcription factors that includes Fos, Jun, and Atf proteins. Batf is expressed in mouse T and B lymphocytes, although the importance of Batf to the function of these lineages has not been fully investigated. We generated mice (Batf(DeltaZ/DeltaZ)) in which Batf protein is not produced. Batf(DeltaZ/DeltaZ) mice contain normal numbers of B cells but show reduced numbers of peripheral CD4(+) T cells. Analysis of CD4(+) T helper (Th) cell subsets in Batf(DeltaZ/DeltaZ) mice demonstrated that Batf is required for the development of functional Th type 17 (Th17), Th2, and follicular Th (Tfh) cells. In response to antigen immunization, germinal centers were absent in Batf(DeltaZ/DeltaZ) mice and the maturation of Ig-secreting B cells was impaired. Although adoptive transfer experiments confirmed that this B cell phenotype can be driven by defects in the Batf(DeltaZ/DeltaZ) CD4(+) T cell compartment, stimulation of Batf(DeltaZ/DeltaZ) B cells in vitro, or by a T cell-independent antigen in vivo, resulted in proliferation but not class-switch recombination. We conclude that loss of Batf disrupts multiple components of the lymphocyte communication network that are required for a robust immune response.

Pubmed ID: 20421391

Authors

  • Betz BC
  • Jordan-Williams KL
  • Wang C
  • Kang SG
  • Liao J
  • Logan MR
  • Kim CH
  • Taparowsky EJ

Journal

The Journal of experimental medicine

Publication Data

May 10, 2010

Associated Grants

  • Agency: NCRR NIH HHS, Id: 5TL1 RR025759
  • Agency: NIAID NIH HHS, Id: AI074745
  • Agency: NCI NIH HHS, Id: CA114381
  • Agency: NCI NIH HHS, Id: CA782464
  • Agency: NIAID NIH HHS, Id: R01 AI074745
  • Agency: NIAID NIH HHS, Id: R01 AI080769
  • Agency: NIGMS NIH HHS, Id: T32 GM08298

Mesh Terms

  • Animals
  • Antibody Formation
  • B-Lymphocytes
  • Basic-Leucine Zipper Transcription Factors
  • CD4 Lymphocyte Count
  • CD4-Positive T-Lymphocytes
  • Cell Differentiation
  • DNA Primers
  • Interleukins
  • Lymphocyte Count
  • Mice
  • Polymerase Chain Reaction
  • RNA
  • Sequence Deletion
  • T-Lymphocytes
  • T-Lymphocytes, Regulatory
  • Th1 Cells
  • Th2 Cells