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Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo.

PloS one | 2010

The low-density lipoprotein (LDL) receptor gene family is a highly conserved group of membrane receptors with diverse functions in developmental processes, lipoprotein trafficking, and cell signaling. The low-density lipoprotein (LDL) receptor-related protein 1b (LRP1B) was reported to be deleted in several types of human malignancies, including non-small cell lung cancer. Our group has previously reported that a distal extracellular truncation of murine Lrp1b that is predicted to secrete the entire intact extracellular domain (ECD) is fully viable with no apparent phenotype.

Pubmed ID: 20383322 RIS Download

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Associated grants

  • Agency: Wellcome Trust, United Kingdom
  • Agency: NHLBI NIH HHS, United States
    Id: R37 HL063762
  • Agency: Cancer Research UK, United Kingdom

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