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Using a latent variable approach to inform gender and racial/ethnic differences in cocaine dependence: a National Drug Abuse Treatment Clinical Trials Network study.

This study applies a latent variable approach to examine gender and racial/ethnic differences in cocaine dependence, to determine the presence of differential item functioning (DIF) or item-response bias to diagnostic questions of cocaine dependence, and to explore the effects of DIF on the predictor analysis of cocaine dependence. The analysis sample included 682 cocaine users enrolled in two national multisite studies of the National Drug Abuse Treatment Clinical Trials Network (CTN). Participants were recruited from 14 community-based substance abuse treatment programs associated with the CTN, including 6 methadone and 8 outpatient nonmethadone programs. Factor and multiple indicators-multiple causes (MIMIC) procedures evaluated the latent continuum of cocaine dependence and its correlates. MIMIC analysis showed that men exhibited lower odds of cocaine dependence than women (regression coefficient, beta = -0.34), controlling for the effects of DIF, years of cocaine use, addiction treatment history, comorbid drug dependence diagnoses, and treatment setting. There were no racial/ethnic differences in cocaine dependence; however, DIF by race/ethnicity was noted. Within the context of multiple community-based addiction treatment settings, women were more likely than men to exhibit cocaine dependence. Addiction treatment research needs to further evaluate gender-related differences in drug dependence in treatment entry and to investigate how these differences may affect study participation, retention, and treatment response to better serve this population.

Pubmed ID: 20307798

Authors

  • Wu LT
  • Pan JJ
  • Blazer DG
  • Tai B
  • Stitzer ML
  • Woody GE

Journal

Journal of substance abuse treatment

Publication Data

June 23, 2010

Associated Grants

  • Agency: NIDA NIH HHS, Id: 5U10DA013034
  • Agency: NIDA NIH HHS, Id: HHSN271200522071C
  • Agency: PHS HHS, Id: HHSN271200522071C
  • Agency: NIDA NIH HHS, Id: K05 DA017009
  • Agency: NIDA NIH HHS, Id: K05 DA017009-07
  • Agency: NIDA NIH HHS, Id: K05DA017009
  • Agency: NIDA NIH HHS, Id: R01 DA019623
  • Agency: NIDA NIH HHS, Id: R01 DA019623
  • Agency: NIDA NIH HHS, Id: R01 DA019623-03
  • Agency: NIDA NIH HHS, Id: R01 DA019901
  • Agency: NIDA NIH HHS, Id: R01 DA019901-03
  • Agency: NIDA NIH HHS, Id: R01DA019623
  • Agency: NIDA NIH HHS, Id: R01DA019901
  • Agency: NIDA NIH HHS, Id: R21 DA 027503
  • Agency: NIDA NIH HHS, Id: R21 DA027503
  • Agency: NIDA NIH HHS, Id: R21 DA027503-01
  • Agency: NIDA NIH HHS, Id: R21DA027503
  • Agency: NIDA NIH HHS, Id: R33 DA027503
  • Agency: NIDA NIH HHS, Id: U10 DA013034
  • Agency: NIDA NIH HHS, Id: U10 DA013034-10
  • Agency: NIDA NIH HHS, Id: U10 DA013043
  • Agency: NIDA NIH HHS, Id: U10 DA013043-10
  • Agency: NIDA NIH HHS, Id: U10DA013043

Mesh Terms

  • Adult
  • Bias (Epidemiology)
  • Clinical Trials as Topic
  • Cocaine-Related Disorders
  • Community Health Services
  • Continental Population Groups
  • Data Collection
  • Data Interpretation, Statistical
  • Ethnic Groups
  • Female
  • Humans
  • Male
  • Methadone
  • Narcotics
  • National Institute on Drug Abuse (U.S.)
  • Sex Factors
  • Substance Abuse Treatment Centers
  • United States