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Male development of chromosomally female mice transgenic for Sry.

The initiation of male development in mammals requires one or more genes on the Y chromosome. A recently isolated gene, termed SRY in humans and Sry in mouse, has many of the genetic and biological properties expected of a Y-located testis-determining gene. It is now shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis differentiation and subsequent male development when introduced into chromosomally female mouse embryos.

Pubmed ID: 2030730


  • Koopman P
  • Gubbay J
  • Vivian N
  • Goodfellow P
  • Lovell-Badge R



Publication Data

May 9, 1991

Associated Grants

  • Agency: Medical Research Council, Id: MC_U117562207

Mesh Terms

  • Animals
  • DNA
  • Female
  • Humans
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred CBA
  • Mice, Transgenic
  • Morphogenesis
  • Phenotype
  • Regulatory Sequences, Nucleic Acid
  • Restriction Mapping
  • Sex Determination Analysis
  • Species Specificity
  • Testis
  • X Chromosome
  • Y Chromosome