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Male development of chromosomally female mice transgenic for Sry.

Nature | May 9, 1991

http://www.ncbi.nlm.nih.gov/pubmed/2030730

The initiation of male development in mammals requires one or more genes on the Y chromosome. A recently isolated gene, termed SRY in humans and Sry in mouse, has many of the genetic and biological properties expected of a Y-located testis-determining gene. It is now shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis differentiation and subsequent male development when introduced into chromosomally female mouse embryos.

Pubmed ID: 2030730 RIS Download

Mesh terms: Animals | DNA | Female | Humans | Male | Mice | Mice, Inbred C57BL | Mice, Inbred CBA | Mice, Transgenic | Morphogenesis | Phenotype | Regulatory Sequences, Nucleic Acid | Restriction Mapping | Sex Determination Analysis | Species Specificity | Testis | X Chromosome | Y Chromosome

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Associated grants

  • Agency: Medical Research Council, Id: MC_U117562207

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