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Hippo, a Drosophila serine/threonine kinase, promotes apoptosis and restricts cell growth and proliferation. Its mammalian homolog MST2 has been shown to play similar role and be regulated by Raf-1 via a kinase-independent mechanism and by RASSF family proteins through forming complex with MST2. However, regulation of MST2 by cell survival signal remains largely unknown.
Pubmed ID: 20231902 RIS Download
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Cell line COS-7 is a Transformed cell line with a species of origin Chlorocebus aethiops (Green monkey)
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