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Transcriptional regulation of VEGF-A by the unfolded protein response pathway.

PloS one | 2010

Angiogenesis is crucial to many physiological and pathological processes including development and cancer cell survival. Vascular endothelial growth factor-A (VEGFA) is the predominant mediator of angiogenesis in the VEGF family. During development, adverse environmental conditions like nutrient deprivation, hypoxia and increased protein secretion occur. IRE1alpha, PERK, and ATF6alpha, master regulators of the unfolded protein response (UPR), are activated under these conditions and are proposed to have a role in mediating angiogenesis.

Pubmed ID: 20221394 RIS Download

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Associated grants

  • Agency: NIDDK NIH HHS, United States
    Id: P30 DK032520
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK067493
  • Agency: NIDDK NIH HHS, United States
    Id: DK032520
  • Agency: NIDDK NIH HHS, United States
    Id: R01DK067493

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