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Host determinants of HIV-1 control in African Americans.

We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associations. We use a subset of patients to demonstrate that this SNP reflects the effect of the HLA-B*5703 allele, which shows a genome-wide statistically significant association with viral load set point (P = 5.6 x 10(-10)). These analyses therefore confirm a member of the HLA-B*57 group of alleles as the most important common variant that influences viral load variation in African Americans, which is consistent with what has been observed for individuals of European ancestry, among whom the most important common variant is HLA-B*5701.

Pubmed ID: 20205591 RIS Download

Mesh terms: Adolescent | Adult | African Americans | DNA-Binding Proteins | Disease Progression | Genome-Wide Association Study | Genotype | HIV Infections | HIV-1 | HLA-B Antigens | HLA-C Antigens | Humans | Male | Middle Aged | Phenotype | Polymorphism, Single Nucleotide | Viral Load | Young Adult

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Associated grants

  • Agency: NCI NIH HHS, Id: K07 CA140360
  • Agency: NIAID NIH HHS, Id: HU0001-05-2-0011
  • Agency: NIAID NIH HHS, Id: U01 AI035042
  • Agency: NIAID NIH HHS, Id: U01 AI037984
  • Agency: NIAID NIH HHS, Id: U01-AI-35043
  • Agency: NIAID NIH HHS, Id: U01 AI067854
  • Agency: NIAID NIH HHS, Id: U01-AI-35042
  • Agency: NIGMS NIH HHS, Id: T32 GM007754
  • Agency: NIAID NIH HHS, Id: U01-AI-37613
  • Agency: NCRR NIH HHS, Id: 5-M01-RR-00052
  • Agency: NIGMS NIH HHS, Id: 5 T32 GM007754-29
  • Agency: NIAID NIH HHS, Id: U01 AI037613
  • Agency: NIAID NIH HHS, Id: U01-AI-35041
  • Agency: NIAID NIH HHS, Id: U01 AI035041
  • Agency: NIAID NIH HHS, Id: AI067854
  • Agency: NIAID NIH HHS, Id: Y1-AI-5072
  • Agency: PHS HHS, Id: HU0001-05-2-0011
  • Agency: NIAID NIH HHS, Id: U19 AI067854
  • Agency: NCRR NIH HHS, Id: M01 RR000052
  • Agency: NIAID NIH HHS, Id: U01-AI-35040
  • Agency: PHS HHS, Id: HHSN261200800001E
  • Agency: NIAID NIH HHS, Id: U01-AI-37984
  • Agency: NIAID NIH HHS, Id: U01 AI035043
  • Agency: NIAID NIH HHS, Id: U01-AI-35039
  • Agency: NIAID NIH HHS, Id: U01 AI035040
  • Agency: CCR NIH HHS, Id: HHSN261200800001C
  • Agency: NIAID NIH HHS, Id: Y01 AI005072
  • Agency: NIAID NIH HHS, Id: U01 AI035039
  • Agency: NCI NIH HHS, Id: HHSN261200800001E

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