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Reduced limbic and hypothalamic volumes correlate with bone density in early Alzheimer's disease.

Accelerated bone loss is associated with Alzheimer's disease (AD). Although the central nervous system plays a direct role in regulating bone mass, primarily through the actions of the hypothalamus, there is little work investigating the possible role of neurodegeneration in bone loss. In this cross-sectional study, we examined the association between bone mineral density (BMD) and neuroimaging markers of neurodegeneration (i.e., global and regional measures of brain volume) in early AD and non-demented aging. Fifty-five non-demented and 63 early AD participants underwent standard neurological and neuropsychological assessment, structural MRI scanning, and dual energy x-ray absorptiometry. In early AD, voxel-based morphometry analyses demonstrated that low BMD was associated with low volume in limbic grey matter (GM) including the hypothalamus, cingulate, and parahippocampal gyri and in the left superior temporal gyrus and left inferior parietal cortex. No relationship between BMD and regional GM volume was found in non-demented controls. The hypothesis-driven region of interest analysis further isolating the hypothalamus demonstrated a positive relationship between BMD and hypothalamic volume after controlling for age and gender in the early AD group but not in non-demented controls. These results demonstrate that lower BMD is associated with lower hypothalamic volume in early AD, suggesting that central mechanisms of bone remodeling may be disrupted by neurodegeneration.

Pubmed ID: 20164583 RIS Download

Mesh terms: Aged | Aged, 80 and over | Alzheimer Disease | Bone Density | Brain Mapping | Female | Humans | Hypothalamus | Image Processing, Computer-Assisted | Limbic System | Magnetic Resonance Imaging | Male | Psychiatric Status Rating Scales | Statistics as Topic

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Associated grants

  • Agency: NIA NIH HHS, Id: R21 AG029615-02
  • Agency: PHS HHS, Id: T32 H0057850-01 A1
  • Agency: NCRR NIH HHS, Id: M01RR023940
  • Agency: NINDS NIH HHS, Id: R01 NS039123
  • Agency: NIA NIH HHS, Id: R21AG029615
  • Agency: NIA NIH HHS, Id: R03 AG026374-01
  • Agency: NICHD NIH HHS, Id: T32 HD057850
  • Agency: NINDS NIH HHS, Id: K23 NS058252
  • Agency: NICHD NIH HHS, Id: R21 HD050534
  • Agency: NIA NIH HHS, Id: R03 AG026374-02
  • Agency: NIDDK NIH HHS, Id: R01 DK080090
  • Agency: NIA NIH HHS, Id: R21 AG026482
  • Agency: NICHD NIH HHS, Id: T32 HD057850-01A1
  • Agency: NIA NIH HHS, Id: R21 AG029615-01A1
  • Agency: NCRR NIH HHS, Id: P20 RR015563
  • Agency: NCRR NIH HHS, Id: M01 RR023940
  • Agency: NIA NIH HHS, Id: R21 AG029615
  • Agency: NIA NIH HHS, Id: R03AG026374
  • Agency: NIA NIH HHS, Id: R03 AG026374
  • Agency: NINDS NIH HHS, Id: K23NS058252

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