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Reduced limbic and hypothalamic volumes correlate with bone density in early Alzheimer's disease.

Accelerated bone loss is associated with Alzheimer's disease (AD). Although the central nervous system plays a direct role in regulating bone mass, primarily through the actions of the hypothalamus, there is little work investigating the possible role of neurodegeneration in bone loss. In this cross-sectional study, we examined the association between bone mineral density (BMD) and neuroimaging markers of neurodegeneration (i.e., global and regional measures of brain volume) in early AD and non-demented aging. Fifty-five non-demented and 63 early AD participants underwent standard neurological and neuropsychological assessment, structural MRI scanning, and dual energy x-ray absorptiometry. In early AD, voxel-based morphometry analyses demonstrated that low BMD was associated with low volume in limbic grey matter (GM) including the hypothalamus, cingulate, and parahippocampal gyri and in the left superior temporal gyrus and left inferior parietal cortex. No relationship between BMD and regional GM volume was found in non-demented controls. The hypothesis-driven region of interest analysis further isolating the hypothalamus demonstrated a positive relationship between BMD and hypothalamic volume after controlling for age and gender in the early AD group but not in non-demented controls. These results demonstrate that lower BMD is associated with lower hypothalamic volume in early AD, suggesting that central mechanisms of bone remodeling may be disrupted by neurodegeneration.

Pubmed ID: 20164583

Authors

  • Loskutova N
  • Honea RA
  • Brooks WM
  • Burns JM

Journal

Journal of Alzheimer's disease : JAD

Publication Data

April 9, 2010

Associated Grants

  • Agency: NINDS NIH HHS, Id: K23NS058252
  • Agency: NCRR NIH HHS, Id: M01RR023940
  • Agency: NCRR NIH HHS, Id: P20 RR015563
  • Agency: NIDDK NIH HHS, Id: R01 DK080090
  • Agency: NINDS NIH HHS, Id: R01 NS039123
  • Agency: NIA NIH HHS, Id: R03 AG026374
  • Agency: NIA NIH HHS, Id: R03 AG026374-01
  • Agency: NIA NIH HHS, Id: R03 AG026374-02
  • Agency: NIA NIH HHS, Id: R03AG026374
  • Agency: NIA NIH HHS, Id: R21 AG026482
  • Agency: NIA NIH HHS, Id: R21 AG029615
  • Agency: NIA NIH HHS, Id: R21 AG029615-01A1
  • Agency: NIA NIH HHS, Id: R21 AG029615-02
  • Agency: NICHD NIH HHS, Id: R21 HD050534
  • Agency: NIA NIH HHS, Id: R21AG029615
  • Agency: PHS HHS, Id: T32 H0057850-01 A1
  • Agency: NICHD NIH HHS, Id: T32 HD057850
  • Agency: NICHD NIH HHS, Id: T32 HD057850-01A1

Mesh Terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease
  • Bone Density
  • Brain Mapping
  • Female
  • Humans
  • Hypothalamus
  • Image Processing, Computer-Assisted
  • Limbic System
  • Magnetic Resonance Imaging
  • Male
  • Psychiatric Status Rating Scales
  • Statistics as Topic