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The relationship between depression and smoking cessation outcomes in treatment-seeking substance abusers.

The National Drug Abuse Treatment Clinical Trials Network (CTN) recently completed a randomized, open label trial comparing treatment as usual (TAU) combined with nicotine patches plus cognitive behavioral group counseling for smoking cessation (n = 153) to TAU alone (n = 72) for patients enrolled in treatment programs for drug or alcohol dependence, who were interested in quitting smoking. This report is a secondary analysis evaluating the effect of depressive symptomatology (n = 70) or history of depression (n = 110) on smoking cessation outcomes. A significant association was seen between measures of depression and difficulty quitting cigarettes. Specifically, there was a greater probability for smoking abstinence for those with lower baseline Beck Depression Inventory II (BDI-II) scores. These data suggest that evaluation and treatment of depressive symptoms may play an important role in improving smoking cessation outcomes. (Am J Addict 2010;00:1-8).

Pubmed ID: 20163382


  • Sonne SC
  • Nunes EV
  • Jiang H
  • Tyson C
  • Rotrosen J
  • Reid MS


The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions

Publication Data

February 18, 2010

Associated Grants

  • Agency: NIDA NIH HHS, Id: K24 DA022412
  • Agency: NIDA NIH HHS, Id: U10 DA013035
  • Agency: NIDA NIH HHS, Id: U10 DA013035-07
  • Agency: NIDA NIH HHS, Id: U10 DA013046-09
  • Agency: NIDA NIH HHS, Id: U10 DA013727
  • Agency: NIDA NIH HHS, Id: U10 DA013727-08
  • Agency: NIDA NIH HHS, Id: U10 DA013727-09
  • Agency: NIDA NIH HHS, Id: U10 DA013727-10
  • Agency: NIDA NIH HHS, Id: U10 DA13035
  • Agency: NIDA NIH HHS, Id: U10 DA13046
  • Agency: NIDA NIH HHS, Id: U10 DA13727

Mesh Terms

  • Administration, Cutaneous
  • Adolescent
  • Adult
  • Behavior, Addictive
  • Cognitive Therapy
  • Combined Modality Therapy
  • Depressive Disorder, Major
  • Diagnosis, Dual (Psychiatry)
  • Female
  • Humans
  • Male
  • Nicotine
  • Patient Acceptance of Health Care
  • Psychotherapy, Group
  • Smoking Cessation
  • Substance-Related Disorders
  • Treatment Outcome