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Regulation of IL-9 expression by IL-25 signaling.

Nature immunology | Mar 16, 2010

The physiological regulation of the expression of interleukin (IL)-9, a cytokine traditionally regarded as being T(H)2 associated, remains unclear. Here, we show that IL-9-expressing T cells generated in vitro in the presence of transforming growth factor-beta and IL-4 express high levels of mRNA for IL-17 receptor B (IL-17RB), the receptor for IL-25. Treatment of these cells with IL-25 enhances IL-9 expression in vitro. Moreover, transgenic and retroviral overexpression of IL-17RB in T cells results in IL-25-induced IL-9 production that is IL-4 independent. In vivo, the IL-25-IL-17RB pathway regulates IL-9 expression in allergic airway inflammation. Thus, IL-25 is a newly identified regulator of IL-9 expression.

Pubmed ID: 20154671 RIS Download

Mesh terms: Animals | Bronchial Hyperreactivity | Bronchoalveolar Lavage Fluid | Cell Count | Disease Models, Animal | Gene Expression Regulation | Interleukin-9 | Interleukins | Mice | Mice, Transgenic | RNA, Messenger | Receptors, Interleukin-17 | Reverse Transcriptase Polymerase Chain Reaction | Signal Transduction | T-Lymphocytes

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Associated grants

  • Agency: NIAMS NIH HHS, Id: RC2 AR059010-01
  • Agency: NIAID NIH HHS, Id: U19 AI071130-04S17898
  • Agency: NIAID NIH HHS, Id: U19 AI071130
  • Agency: NIAMS NIH HHS, Id: R01 AR050772-08
  • Agency: NIAMS NIH HHS, Id: R01 AR050772-07
  • Agency: NIAMS NIH HHS, Id: RC2 AR059010
  • Agency: NIAID NIH HHS, Id: U19 AI071130-030006
  • Agency: NIAMS NIH HHS, Id: R01 AR050772
  • Agency: NIAID NIH HHS, Id: U19 AI071130-040006

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