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Regulation of IL-9 expression by IL-25 signaling.

The physiological regulation of the expression of interleukin (IL)-9, a cytokine traditionally regarded as being T(H)2 associated, remains unclear. Here, we show that IL-9-expressing T cells generated in vitro in the presence of transforming growth factor-beta and IL-4 express high levels of mRNA for IL-17 receptor B (IL-17RB), the receptor for IL-25. Treatment of these cells with IL-25 enhances IL-9 expression in vitro. Moreover, transgenic and retroviral overexpression of IL-17RB in T cells results in IL-25-induced IL-9 production that is IL-4 independent. In vivo, the IL-25-IL-17RB pathway regulates IL-9 expression in allergic airway inflammation. Thus, IL-25 is a newly identified regulator of IL-9 expression.

Pubmed ID: 20154671

Authors

  • Angkasekwinai P
  • Chang SH
  • Thapa M
  • Watarai H
  • Dong C

Journal

Nature immunology

Publication Data

March 16, 2010

Associated Grants

  • Agency: NIAMS NIH HHS, Id: R01 AR050772
  • Agency: NIAMS NIH HHS, Id: R01 AR050772-07
  • Agency: NIAMS NIH HHS, Id: R01 AR050772-08
  • Agency: NIAMS NIH HHS, Id: RC2 AR059010
  • Agency: NIAMS NIH HHS, Id: RC2 AR059010-01
  • Agency: NIAID NIH HHS, Id: U19 AI071130
  • Agency: NIAID NIH HHS, Id: U19 AI071130-030006
  • Agency: NIAID NIH HHS, Id: U19 AI071130-040006
  • Agency: NIAID NIH HHS, Id: U19 AI071130-04S17898

Mesh Terms

  • Animals
  • Bronchial Hyperreactivity
  • Bronchoalveolar Lavage Fluid
  • Cell Count
  • Disease Models, Animal
  • Gene Expression Regulation
  • Interleukin-9
  • Interleukins
  • Mice
  • Mice, Transgenic
  • RNA, Messenger
  • Receptors, Interleukin-17
  • Reverse Transcriptase Polymerase Chain Reaction
  • Signal Transduction
  • T-Lymphocytes