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Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior.

Neuroligins (NLs) are a family of neural cell-adhesion molecules that are involved in excitatory/inhibitory synapse specification. Multiple members of the NL family (including NL1) and their binding partners have been linked to cases of human autism and mental retardation. We have now characterized NL1-deficient mice in autism- and mental retardation-relevant behavioral tasks. NL1 knock-out (KO) mice display deficits in spatial learning and memory that correlate with impaired hippocampal long-term potentiation. In addition, NL1 KO mice exhibit a dramatic increase in repetitive, stereotyped grooming behavior, a potential autism-relevant abnormality. This repetitive grooming abnormality in NL1 KO mice is associated with a reduced NMDA/AMPA ratio at corticostriatal synapses. Interestingly, we further demonstrate that the increased repetitive grooming phenotype can be rescued in adult mice by administration of the NMDA receptor partial coagonist d-cycloserine. Broadly, these data are consistent with a role of synaptic cell-adhesion molecules in general, and NL1 in particular, in autism and implicate reduced excitatory synaptic transmission as a potential mechanism and treatment target for repetitive behavioral abnormalities.

Pubmed ID: 20147539 RIS Download

Mesh terms: Animals | Cell Adhesion Molecules, Neuronal | Cerebral Cortex | Corpus Striatum | Cycloserine | Drug Partial Agonism | Excitatory Postsynaptic Potentials | Grooming | Hippocampus | Long-Term Potentiation | Maze Learning | Membrane Proteins | Memory | Mice | Mice, Knockout | Nerve Tissue Proteins | Neural Cell Adhesion Molecules | Patch-Clamp Techniques | Receptors, AMPA | Receptors, N-Methyl-D-Aspartate | Social Behavior | Spatial Behavior | Stereotyped Behavior | Synapses

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Associated grants

  • Agency: NIMH NIH HHS, Id: K08 MH065975
  • Agency: NICHD NIH HHS, Id: R21 HD065290-01
  • Agency: NIMH NIH HHS, Id: R37 MH052804
  • Agency: NIMH NIH HHS, Id: R01 MH081164-01A2
  • Agency: NIMH NIH HHS, Id: R37 MH52804-08
  • Agency: NIMH NIH HHS, Id: R01 MH081164-02
  • Agency: NIMH NIH HHS, Id: MH065975-05
  • Agency: NIMH NIH HHS, Id: R01 MH081164
  • Agency: NICHD NIH HHS, Id: R21 HD065290
  • Agency: Autism Speaks, Id: AS2126
  • Agency: Autism Speaks, Id: AS1264

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