Genetic fate mapping reveals that the caudal ganglionic eminence produces a large and diverse population of superficial cortical interneurons.
By combining an inducible genetic fate mapping strategy with electrophysiological analysis, we have systematically characterized the populations of cortical GABAergic interneurons that originate from the caudal ganglionic eminence (CGE). Interestingly, compared with medial ganglionic eminence (MGE)-derived cortical interneuron populations, the initiation [embryonic day 12.5 (E12.5)] and peak production (E16.5) of interneurons from this embryonic structure occurs 3 d later in development. Moreover, unlike either pyramidal cells or MGE-derived cortical interneurons, CGE-derived interneurons do not integrate into the cortex in an inside-out manner but preferentially (75%) occupy superficial cortical layers independent of birthdate. In contrast to previous estimates, CGE-derived interneurons are both considerably greater in number (approximately 30% of all cortical interneurons) and diversity (comprised by at least nine distinct subtypes). Furthermore, we found that a large proportion of CGE-derived interneurons, including the neurogliaform subtype, express the glycoprotein Reelin. In fact, most CGE-derived cortical interneurons express either Reelin or vasoactive intestinal polypeptide. Thus, in conjunction with previous studies, we have now determined the spatial and temporal origins of the vast majority of cortical interneuron subtypes.
The Journal of neuroscience : the official journal of the Society for Neuroscience
February 3, 2010
Agency: NIMH NIH HHS, Id: R01 MH071679
Agency: NIMH NIH HHS, Id: R01 MH071679-01A1
Agency: NIMH NIH HHS, Id: R01 MH071679-02
Agency: NIMH NIH HHS, Id: R01 MH071679-03
Agency: NIMH NIH HHS, Id: R01 MH071679-04
Agency: NIMH NIH HHS, Id: R01 MH071679-05
Agency: NINDS NIH HHS, Id: R01 NS039007
Agency: NINDS NIH HHS, Id: R01 NS039007-08
Agency: NINDS NIH HHS, Id: R01 NS039007-09A1
Agency: NINDS NIH HHS, Id: R01 NS039007-10
Agency: NIMH NIH HHS, Id: R01MH071679
Agency: NINDS NIH HHS, Id: R01NS039007
Cell Adhesion Molecules, Neuronal
Extracellular Matrix Proteins
Nerve Tissue Proteins
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