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Chemical reprogramming of Caenorhabditis elegans germ cell fate.

Small molecules can control cell fate in vivo and may allow directed induction of desired cell types, providing an attractive alternative to transplant-based approaches in regenerative medicine. We have chemically induced functional oocytes in Caenorhabditis elegans adults that otherwise produced only sperm. These findings suggest that chemical approaches to therapeutic cell reprogramming may be feasible and provide a powerful platform for analyzing molecular mechanisms of in vivo cell reprogramming.

Pubmed ID: 20081824

Authors

  • Morgan CT
  • Lee MH
  • Kimble J

Journal

Nature chemical biology

Publication Data

February 18, 2010

Associated Grants

  • Agency: NIGMS NIH HHS, Id: R01 GM069454
  • Agency: NIGMS NIH HHS, Id: R01 GM069454
  • Agency: NIGMS NIH HHS, Id: R01 GM069454-04
  • Agency: NIGMS NIH HHS, Id: R01 GM069454-05A1
  • Agency: Howard Hughes Medical Institute, Id:
  • Agency: Howard Hughes Medical Institute, Id:

Mesh Terms

  • Animals
  • Butadienes
  • Caenorhabditis elegans
  • Cell Differentiation
  • Cell Lineage
  • Cellular Reprogramming
  • Female
  • MAP Kinase Signaling System
  • Male
  • Molecular Structure
  • Nitriles
  • Oocytes
  • Spermatozoa