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Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction.

Developmental cell | Dec 11, 2009

http://www.ncbi.nlm.nih.gov/pubmed/20059955

During the assembly of the musculoskeletal system, bone ridges provide a stable anchoring point and stress dissipation for the attachment of muscles via tendons to the skeleton. In this study, we investigate the development of the deltoid tuberosity as a model for bone ridge formation. We show that the deltoid tuberosity develops through endochondral ossification in a two-phase process: initiation is regulated by a signal from the tendons, whereas the subsequent growth phase is muscle dependent. We then show that the transcription factor scleraxis (SCX) regulates Bmp4 in tendon cells at their insertion site. The inhibition of deltoid tuberosity formation and several other bone ridges in embryos in which Bmp4 expression was blocked specifically in Scx-expressing cells implicates BMP4 as a key mediator of tendon effects on bone ridge formation. This study establishes a mechanistic basis for tendon-skeleton regulatory interactions during musculoskeletal assembly and bone secondary patterning.

Pubmed ID: 20059955 RIS Download

Mesh terms: Animals | Basic Helix-Loop-Helix Transcription Factors | Bone Morphogenetic Protein 4 | Embryo, Mammalian | Gene Expression Regulation, Developmental | Mice | Osteogenesis | Tendons

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Associated grants

  • Agency: NICHD NIH HHS, Id: F32HD057701
  • Agency: NIDDK NIH HHS, Id: P01 DK056246
  • Agency: NIDDK NIH HHS, Id: P01 DK056246-10
  • Agency: NIDDK NIH HHS, Id: P01 DK56246
  • Agency: NIAMS NIH HHS, Id: R01 AR055640

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