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A reprogrammable mouse strain from gene-targeted embryonic stem cells.

Nature methods | Jan 29, 2010

The derivation of induced pluripotent stem cells (iPSCs) usually involves the viral introduction of reprogramming factors into somatic cells. Here we used gene targeting to generate a mouse strain with a single copy of an inducible, polycistronic reprogramming cassette, allowing for the induction of pluripotency in various somatic cell types. As these 'reprogrammable mice' can be easily bred, they are a useful tool to study the mechanisms underlying cellular reprogramming.

Pubmed ID: 20010832 RIS Download

Mesh terms: Animals | Blood Cells | Cell Dedifferentiation | Cell Lineage | Cells, Cultured | Cellular Reprogramming | Collagen | DNA Nucleotidyltransferases | Doxycycline | Embryonic Stem Cells | Fibroblasts | Gene Targeting | Induced Pluripotent Stem Cells | Mice | Mice, Mutant Strains | Mutagenesis, Insertional

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