Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

A reprogrammable mouse strain from gene-targeted embryonic stem cells.

The derivation of induced pluripotent stem cells (iPSCs) usually involves the viral introduction of reprogramming factors into somatic cells. Here we used gene targeting to generate a mouse strain with a single copy of an inducible, polycistronic reprogramming cassette, allowing for the induction of pluripotency in various somatic cell types. As these 'reprogrammable mice' can be easily bred, they are a useful tool to study the mechanisms underlying cellular reprogramming.

Pubmed ID: 20010832


  • Stadtfeld M
  • Maherali N
  • Borkent M
  • Hochedlinger K


Nature methods

Publication Data

January 29, 2010

Associated Grants

  • Agency: NIH HHS, Id: DP2 OD003266

Mesh Terms

  • Animals
  • Blood Cells
  • Cell Dedifferentiation
  • Cell Lineage
  • Cells, Cultured
  • Cellular Reprogramming
  • Collagen
  • DNA Nucleotidyltransferases
  • Doxycycline
  • Embryonic Stem Cells
  • Fibroblasts
  • Gene Targeting
  • Induced Pluripotent Stem Cells
  • Mice
  • Mice, Mutant Strains
  • Mutagenesis, Insertional