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Characterization of the histone H2A.Z-1 and H2A.Z-2 isoforms in vertebrates.

BMC biology | 2009

Within chromatin, the histone variant H2A.Z plays a role in many diverse nuclear processes including transcription, preventing the spread of heterochromatin and epigenetic transcriptional memory. The molecular mechanisms of how H2A.Z mediates its effects are not entirely understood. However, it is now known that H2A.Z has two protein isoforms in vertebrates, H2A.Z-1 and H2A.Z-2, which are encoded by separate genes and differ by 3 amino acid residues.

Pubmed ID: 20003410 RIS Download

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Associated grants

  • Agency: NIGMS NIH HHS, United States
    Id: R01 GM037537
  • Agency: NIGMS NIH HHS, United States
    Id: GM 37537
  • Agency: CIHR, Canada
    Id: MOP-97878

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