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Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development.

Blood | Jan 21, 2010

http://www.ncbi.nlm.nih.gov/pubmed/19965654

Proper thymocyte development is required to establish T-cell central tolerance and to generate naive T cells, both of which are essential for T-cell homeostasis and a functional immune system. Here we demonstrate that the loss of transcription factor Foxp1 results in the abnormal development of T cells. Instead of generating naive T cells, Foxp1-deficient single-positive thymocytes acquire an activated phenotype prematurely in the thymus and lead to the generation of peripheral CD4(+) T and CD8(+) T cells that exhibit an activated phenotype and increased apoptosis and readily produce cytokines upon T-cell receptor engagement. These results identify Foxp1 as an essential transcriptional regulator for thymocyte development and the generation of quiescent naive T cells.

Pubmed ID: 19965654 RIS Download

Mesh terms: Animals | Apoptosis | Cell Differentiation | Cell Proliferation | Cells, Cultured | Forkhead Transcription Factors | Mice | Mice, Congenic | Mice, Inbred C57BL | Mice, Transgenic | Phenotype | Repressor Proteins | T-Lymphocytes | Thymus Gland | Transcription Factors

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Associated grants

  • Agency: NIAID NIH HHS, Id: 1K22AI070317-01A1
  • Agency: NIAID NIH HHS, Id: AI59166
  • Agency: NCI NIH HHS, Id: CA031534

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