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Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development.

Proper thymocyte development is required to establish T-cell central tolerance and to generate naive T cells, both of which are essential for T-cell homeostasis and a functional immune system. Here we demonstrate that the loss of transcription factor Foxp1 results in the abnormal development of T cells. Instead of generating naive T cells, Foxp1-deficient single-positive thymocytes acquire an activated phenotype prematurely in the thymus and lead to the generation of peripheral CD4(+) T and CD8(+) T cells that exhibit an activated phenotype and increased apoptosis and readily produce cytokines upon T-cell receptor engagement. These results identify Foxp1 as an essential transcriptional regulator for thymocyte development and the generation of quiescent naive T cells.

Pubmed ID: 19965654

Authors

  • Feng X
  • Ippolito GC
  • Tian L
  • Wiehagen K
  • Oh S
  • Sambandam A
  • Willen J
  • Bunte RM
  • Maika SD
  • Harriss JV
  • Caton AJ
  • Bhandoola A
  • Tucker PW
  • Hu H

Journal

Blood

Publication Data

January 21, 2010

Associated Grants

  • Agency: NIAID NIH HHS, Id: 1K22AI070317-01A1
  • Agency: NIAID NIH HHS, Id: AI59166
  • Agency: NCI NIH HHS, Id: CA031534

Mesh Terms

  • Animals
  • Apoptosis
  • Cell Differentiation
  • Cell Proliferation
  • Cells, Cultured
  • Forkhead Transcription Factors
  • Mice
  • Mice, Congenic
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Phenotype
  • Repressor Proteins
  • T-Lymphocytes
  • Thymus Gland
  • Transcription Factors