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Histone acetyltransferase p300 is a coactivator for transcription factor REL and is C-terminally truncated in the human diffuse large B-cell lymphoma cell line RC-K8.

Human c-Rel (REL) is a member of the NF-kappaB family of transcription factors. REL's normal physiological role is in the regulation of B-cell proliferation and survival. The REL gene is amplified in many human B-cell lymphomas and overexpression of REL can transform chicken lymphoid cells. In this report, histone acetyltransferase p300 enhanced REL-induced transactivation and interacted with REL both in vitro and in REL-transformed chicken spleen cells and the B-lymphoma cell line RC-K8, in which REL is constitutively active and required for proliferation. However, due to a deletion in the EP300 locus, only a C-terminally truncated form of p300 is expressed in RC-K8 cells. These results suggest a role for p300 in REL-mediated oncogenic activity in B lymphoma.

Pubmed ID: 19948376

Authors

  • Garbati MR
  • Al├žo G
  • Gilmore TD

Journal

Cancer letters

Publication Data

May 28, 2010

Associated Grants

  • Agency: NCI NIH HHS, Id: CA047763
  • Agency: NCI NIH HHS, Id: CA047763-21S3
  • Agency: NCI NIH HHS, Id: R01 CA047763
  • Agency: NCI NIH HHS, Id: R01 CA047763-21
  • Agency: NCI NIH HHS, Id: R01 CA047763-21S1

Mesh Terms

  • Animals
  • Cell Line, Tumor
  • Cell Transformation, Neoplastic
  • Cells, Cultured
  • Chickens
  • Genes, Reporter
  • Glutathione Transferase
  • Histone Acetyltransferases
  • Humans
  • Kidney
  • Luciferases
  • Lymphoma, B-Cell
  • Lymphoma, Large B-Cell, Diffuse
  • NF-kappa B
  • Polymerase Chain Reaction
  • Proto-Oncogene Proteins c-rel
  • Recombinant Fusion Proteins
  • Transfection