We have updated our privacy policy. If you have any question, contact us at privacy@scicrunch.org. Dismiss and don't show again

Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Leucine-rich repeat transmembrane proteins instruct discrete dendrite targeting in an olfactory map.

Nature neuroscience | Dec 25, 2009

Olfactory systems utilize discrete neural pathways to process and integrate odorant information. In Drosophila, axons of first-order olfactory receptor neurons (ORNs) and dendrites of second-order projection neurons (PNs) form class-specific synaptic connections at approximately 50 glomeruli. The mechanisms underlying PN dendrite targeting to distinct glomeruli in a three-dimensional discrete neural map are unclear. We found that the leucine-rich repeat (LRR) transmembrane protein Capricious (Caps) was differentially expressed in different classes of PNs. Loss-of-function and gain-of-function studies indicated that Caps instructs the segregation of Caps-positive and Caps-negative PN dendrites to discrete glomerular targets. Moreover, Caps-mediated PN dendrite targeting was independent of presynaptic ORNs and did not involve homophilic interactions. The closely related protein Tartan was partially redundant with Caps. These LRR proteins are probably part of a combinatorial cell-surface code that instructs discrete olfactory map formation.

Pubmed ID: 19915565 RIS Download

Mesh terms: Animals | Axons | Dendrites | Drosophila | Drosophila Proteins | Ganglia, Invertebrate | Gene Expression Regulation, Developmental | Leucine | Membrane Proteins | Mutagenesis | Olfactory Pathways | Olfactory Receptor Neurons | Phenotype | Protein Structure, Tertiary | Receptors, Presynaptic

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIDCD NIH HHS, Id: R01-DC005982
  • Agency: NIDCD NIH HHS, Id: R01 DC005982
  • Agency: NIDCD NIH HHS, Id: R01 DC005982-07
  • Agency: Howard Hughes Medical Institute, Id: R01 DC005982-06
  • Agency: NIDCD NIH HHS, Id:

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.