Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes.

Molecular cell | Oct 23, 2009

http://www.ncbi.nlm.nih.gov/pubmed/19854131

Orthologs of the yeast telomere protein Stn1 are present in plants, but other components of the Cdc13/Stn1/Ten1 (CST) complex have only been found in fungi. Here we report the identification of conserved telomere maintenance component 1 (CTC1) in plants and vertebrates. CTC1 encodes an approximately 140 kDa telomere-associated protein predicted to contain multiple OB-fold domains. Arabidopsis mutants null for CTC1 display a severe telomere deprotection phenotype accompanied by a rapid onset of developmental defects and sterility. Telomeric and subtelomeric tracts are dramatically eroded, and chromosome ends exhibit increased G overhangs, recombination, and end-to-end fusions. AtCTC1 both physically and genetically interacts with AtSTN1. Depletion of human CTC1 by RNAi triggers a DNA damage response, chromatin bridges, increased G overhangs, and sporadic telomere loss. These data indicate that CTC1 participates in telomere maintenance in diverse species and that a CST-like complex is required for telomere integrity in multicellular organisms.

Pubmed ID: 19854131 RIS Download

Mesh terms: Anaphase | Arabidopsis | Arabidopsis Proteins | Cell Line, Tumor | Chromosomal Proteins, Non-Histone | Chromosomes, Plant | Conserved Sequence | Eukaryotic Cells | Genomic Instability | Humans | In Situ Hybridization, Fluorescence | Mutation | Nucleic Acid Conformation | Protein Binding | Recombination, Genetic | Telomere | Telomere-Binding Proteins

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIGMS NIH HHS, Id: GM041803
  • Agency: NIGMS NIH HHS, Id: GM065383
  • Agency: NIGMS NIH HHS, Id: GM73169
  • Agency: NIGMS NIH HHS, Id: GM800052
  • Agency: NIGMS NIH HHS, Id: R01 GM041803
  • Agency: NIGMS NIH HHS, Id: R01 GM041803-19
  • Agency: NIGMS NIH HHS, Id: R01 GM073169
  • Agency: NIGMS NIH HHS, Id: R01 GM073169-04

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.