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REBASE--a database for DNA restriction and modification: enzymes, genes and genomes.

REBASE is a comprehensive database of information about restriction enzymes, DNA methyltransferases and related proteins involved in the biological process of restriction-modification (R-M). It contains fully referenced information about recognition and cleavage sites, isoschizomers, neoschizomers, commercial availability, methylation sensitivity, crystal and sequence data. Experimentally characterized homing endonucleases are also included. The fastest growing segment of REBASE contains the putative R-M systems found in the sequence databases. Comprehensive descriptions of the R-M content of all fully sequenced genomes are available including summary schematics. The contents of REBASE may be browsed from the web (http://rebase.neb.com) and selected compilations can be downloaded by ftp (ftp.neb.com). Additionally, monthly updates can be requested via email.

Pubmed ID: 19846593


  • Roberts RJ
  • Vincze T
  • Posfai J
  • Macelis D


Nucleic acids research

Publication Data

January 22, 2010

Associated Grants

  • Agency: NLM NIH HHS, Id: LM04971
  • Agency: NLM NIH HHS, Id: P41 LM005800

Mesh Terms

  • Binding Sites
  • Computational Biology
  • DNA Modification Methylases
  • DNA Restriction Enzymes
  • Databases, Genetic
  • Databases, Protein
  • Genome, Archaeal
  • Genome, Bacterial
  • Genomics
  • Information Storage and Retrieval
  • Internet
  • Protein Structure, Tertiary
  • Software
  • Substrate Specificity