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Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A.

Genes & development | Oct 15, 2009

http://www.ncbi.nlm.nih.gov/pubmed/19833766

Mammary alveologenesis is abrogated in the absence of the transcription factors STAT5A/5B, which mediate cytokine signaling. To reveal the underlying causes for this developmental block, we studied mammary stem and progenitor cells. While loss of STAT5A/5B did not affect the stem cell population and its ability to form mammary ducts, luminal progenitors were greatly reduced and unable to form alveoli during pregnancy. Temporally controlled expression of transgenic STAT5A in mammary epithelium lacking STAT5A/5B restored the luminal progenitor population and rescued alveologenesis in a reversible fashion in vivo. Thus, STAT5A is necessary and sufficient for the establishment of luminal progenitor cells.

Pubmed ID: 19833766 RIS Download

Mesh terms: Animals | Female | Gene Expression Regulation, Developmental | Mammary Glands, Animal | Mice | Mice, Inbred C57BL | Mice, Transgenic | Pregnancy | STAT5 Transcription Factor | Stem Cells

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Associated grants

  • Agency: Intramural NIH HHS, Id:

Mouse Genome Informatics (Data, Gene Annotation)

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