• Register
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.


Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.


Generation and characterization of conditional heparin-binding EGF-like growth factor knockout mice.

Recently, neurotrophic factors and cytokines have been shown to be associated in psychiatric disorders, such as schizophrenia, bipolar disorder, and depression. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the EGF family, serves as a neurotrophic molecular and plays a significant role in the brain. We generated mice in which HB-EGF activity is disrupted specifically in the ventral forebrain. These knockout mice showed (a) behavioral abnormalities similar to those described in psychiatric disorders, which were ameliorated by typical or atypical antipsychotics, (b) altered dopamine and serotonin levels in the brain, (c) decreases in spine density in neurons of the prefrontal cortex, (d) reductions in the protein levels of the NR1 subunit of the N-methyl-D-aspartate (NMDA) receptor and post-synaptic protein-95 (PSD-95), (e) decreases in the EGF receptor, and in the calcium/calmodulin-dependent protein kinase II (CaMK II) signal cascade. These results suggest the alterations affecting HB-EGF signaling could comprise a contributing factor in psychiatric disorder.

Pubmed ID: 19829704


  • Oyagi A
  • Oida Y
  • Kakefuda K
  • Shimazawa M
  • Shioda N
  • Moriguchi S
  • Kitaichi K
  • Nanba D
  • Yamaguchi K
  • Furuta Y
  • Fukunaga K
  • Higashiyama S
  • Hara H


PloS one

Publication Data

October 15, 2009

Associated Grants


Mesh Terms

  • Animals
  • Antipsychotic Agents
  • Behavior, Animal
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2
  • Dopamine
  • Female
  • Heparin-binding EGF-like Growth Factor
  • Intercellular Signaling Peptides and Proteins
  • Intracellular Signaling Peptides and Proteins
  • Male
  • Membrane Proteins
  • Mice
  • Mice, Knockout
  • Neurons
  • Prosencephalon
  • Receptor, Epidermal Growth Factor
  • Receptors, N-Methyl-D-Aspartate
  • Serotonin