MicroRNAs (miRNAs) have been implicated in cancer initiation and progression via their ability to affect expression of genes and proteins that regulate cell proliferation and/or cell death. Transcription of the three miRNA miR-34 family members was recently found to be directly regulated by p53. Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2, suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells.
Pubmed ID: 19714243 RIS Download
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Cell line WI-38 is a Finite cell line with a species of origin Homo sapiens
View all literature mentionsCell line BxPC-3 is a Cancer cell line with a species of origin Homo sapiens (Human)
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