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Generating coherent patterns of activity from chaotic neural networks.

Neural circuits display complex activity patterns both spontaneously and when responding to a stimulus or generating a motor output. How are these two forms of activity related? We develop a procedure called FORCE learning for modifying synaptic strengths either external to or within a model neural network to change chaotic spontaneous activity into a wide variety of desired activity patterns. FORCE learning works even though the networks we train are spontaneously chaotic and we leave feedback loops intact and unclamped during learning. Using this approach, we construct networks that produce a wide variety of complex output patterns, input-output transformations that require memory, multiple outputs that can be switched by control inputs, and motor patterns matching human motion capture data. Our results reproduce data on premovement activity in motor and premotor cortex, and suggest that synaptic plasticity may be a more rapid and powerful modulator of network activity than generally appreciated.

Pubmed ID: 19709635

Authors

  • Sussillo D
  • Abbott LF

Journal

Neuron

Publication Data

August 27, 2009

Associated Grants

  • Agency: NIH HHS, Id: 5-DP1-OD114-02
  • Agency: NIH HHS, Id: DP1 OD000114
  • Agency: NIH HHS, Id: DP1 OD000114-06
  • Agency: NIMH NIH HHS, Id: MH-58754
  • Agency: NIMH NIH HHS, Id: R01 MH058754
  • Agency: NIMH NIH HHS, Id: R01 MH058754-11

Mesh Terms

  • Action Potentials
  • Feedback, Physiological
  • Humans
  • Neural Networks (Computer)
  • Neuronal Plasticity
  • Nonlinear Dynamics