Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Increased volume of the striatum in psychopathic individuals.

BACKGROUND: The corpus striatum, comprised of the caudate, putamen, and globus pallidus, plays an important role in reward processing and may be involved in the pathophysiology of antisocial behavior. Few studies have explored whether differences are present in the striatum of antisocial individuals. Here, we examine the structure of the striatum in relation to psychopathy. METHODS: Using a case-control design, we examined the volume of the striatum in psychopathic individuals compared with control subjects matched for age, sex, ethnicity, and substance dependence. Twenty-two psychopathic individuals assessed using the Psychopathy Checklist-Revised and 22 comparison subjects underwent structural magnetic resonance imaging. Volumes of the left and right lenticular nucleus (putamen and globus pallidus), caudate head, and caudate body were assessed and the psychopathic and control groups were compared. RESULTS: Psychopathic individuals showed a 9.6% increase in striatum volumes. Analyses of subfactors of psychopathy revealed that caudate body volumes were primarily associated with the interpersonal and affective features of psychopathy, while caudate head volumes were primarily associated with the impulsive, stimulation-seeking features. CONCLUSIONS: These findings provide new evidence for differences in the striatum of psychopathic individuals. This structural difference may partially underlie the reward-seeking and decision-making deficits associated with psychopathy.

Pubmed ID: 19683706


  • Glenn AL
  • Raine A
  • Yaralian PS
  • Yang Y


Biological psychiatry

Publication Data

January 1, 2010

Associated Grants

  • Agency: NIMH NIH HHS, Id: 5 R03 MH50940-02
  • Agency: NIMH NIH HHS, Id: K02 MH001114-08
  • Agency: NIMH NIH HHS, Id: K02 MH01114-01
  • Agency: NIMH NIH HHS, Id: K02 MH01114-08

Mesh Terms

  • Adult
  • Antisocial Personality Disorder
  • Brain Mapping
  • Corpus Striatum
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Regression Analysis
  • Statistics, Nonparametric
  • Young Adult