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The transcriptional repressor DEC2 regulates sleep length in mammals.

Sleep deprivation can impair human health and performance. Habitual total sleep time and homeostatic sleep response to sleep deprivation are quantitative traits in humans. Genetic loci for these traits have been identified in model organisms, but none of these potential animal models have a corresponding human genotype and phenotype. We have identified a mutation in a transcriptional repressor (hDEC2-P385R) that is associated with a human short sleep phenotype. Activity profiles and sleep recordings of transgenic mice carrying this mutation showed increased vigilance time and less sleep time than control mice in a zeitgeber time- and sleep deprivation-dependent manner. These mice represent a model of human sleep homeostasis that provides an opportunity to probe the effect of sleep on human physical and mental health.

Pubmed ID: 19679812

Authors

  • He Y
  • Jones CR
  • Fujiki N
  • Xu Y
  • Guo B
  • Holder JL
  • Rossner MJ
  • Nishino S
  • Fu YH

Journal

Science (New York, N.Y.)

Publication Data

August 14, 2009

Associated Grants

  • Agency: NHLBI NIH HHS, Id: HL059596
  • Agency: NIMH NIH HHS, Id: MH074924
  • Agency: NHLBI NIH HHS, Id: R01 HL059596
  • Agency: NHLBI NIH HHS, Id: R01 HL059596-09

Mesh Terms

  • Activity Cycles
  • Adolescent
  • Adult
  • Aged
  • Amino Acid Sequence
  • Amino Acid Substitution
  • Animals
  • Animals, Genetically Modified
  • Basic Helix-Loop-Helix Transcription Factors
  • Child
  • Circadian Rhythm
  • Drosophila
  • Electroencephalography
  • Electromyography
  • Female
  • Homeostasis
  • Humans
  • Male
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Middle Aged
  • Molecular Sequence Data
  • Pedigree
  • Point Mutation
  • Sleep
  • Sleep Deprivation
  • Sleep, REM
  • Transcription Factors
  • Wakefulness