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Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure.

The multisubunit anaphase promoting complex (APC) is an essential cell-cycle regulator. Although CDC26 is known to have a role in APC assembly, its molecular function has remained unclear. Biophysical, structural and genetic studies presented here reveal that CDC26 stabilizes the structure of APC6, a core TPR protein required for APC integrity. Notably, CDC26-APC6 association involves an intermolecular TPR mimic composed of one helix from each protein.

Pubmed ID: 19668213

Authors

  • Wang J
  • Dye BT
  • Rajashankar KR
  • Kurinov I
  • Schulman BA

Journal

Nature structural & molecular biology

Publication Data

September 3, 2009

Associated Grants

  • Agency: NCI NIH HHS, Id: P30 CA021765
  • Agency: NCI NIH HHS, Id: P30 CA021765-29
  • Agency: NCI NIH HHS, Id: P30 CA021765-30
  • Agency: NCI NIH HHS, Id: P30 CA021765-309026
  • Agency: NCI NIH HHS, Id: P30 CA021765-31
  • Agency: Howard Hughes Medical Institute, Id:
  • Agency: Howard Hughes Medical Institute, Id:

Mesh Terms

  • Amino Acid Motifs
  • Amino Acid Sequence
  • Anaphase-Promoting Complex-Cyclosome
  • Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome
  • Cell Cycle Proteins
  • Circular Dichroism
  • Humans
  • Models, Molecular
  • Molecular Sequence Data
  • Protein Binding
  • Protein Structure, Quaternary
  • Protein Structure, Tertiary
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Sequence Alignment
  • Ubiquitin-Protein Ligase Complexes
  • Ubiquitin-Protein Ligases