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Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure.

The multisubunit anaphase promoting complex (APC) is an essential cell-cycle regulator. Although CDC26 is known to have a role in APC assembly, its molecular function has remained unclear. Biophysical, structural and genetic studies presented here reveal that CDC26 stabilizes the structure of APC6, a core TPR protein required for APC integrity. Notably, CDC26-APC6 association involves an intermolecular TPR mimic composed of one helix from each protein.

Pubmed ID: 19668213 RIS Download

Mesh terms: Amino Acid Motifs | Amino Acid Sequence | Anaphase-Promoting Complex-Cyclosome | Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome | Cell Cycle Proteins | Circular Dichroism | Humans | Models, Molecular | Molecular Sequence Data | Protein Binding | Protein Structure, Quaternary | Protein Structure, Tertiary | Saccharomyces cerevisiae | Saccharomyces cerevisiae Proteins | Sequence Alignment | Ubiquitin-Protein Ligase Complexes | Ubiquitin-Protein Ligases

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Associated grants

  • Agency: NCRR NIH HHS, Id: P41 RR015301
  • Agency: NCI NIH HHS, Id: P30 CA021765-30
  • Agency: NCI NIH HHS, Id: P30 CA021765-29
  • Agency: Howard Hughes Medical Institute, Id: P30 CA021765
  • Agency: NCI NIH HHS, Id: P30 CA021765-31
  • Agency: NCI NIH HHS, Id: P30 CA021765-309026
  • Agency: NCI NIH HHS, Id:

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