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Multisite randomized trial of behavioral interventions for women with co-occurring PTSD and substance use disorders.

http://www.ncbi.nlm.nih.gov/pubmed/19634955

The authors compared the effectiveness of the Seeking Safety group, cognitive-behavioral treatment for substance use disorder and posttraumatic stress disorder (PTSD), to an active comparison health education group (Women's Health Education [WHE]) within the National Institute on Drug Abuse's Clinical Trials Network. The authors randomized 353 women to receive 12 sessions of Seeking Safety (M = 6.2 sessions) or WHE (M = 6.0 sessions) with follow-up assessment 1 week and 3, 6, and 12 months posttreatment. Primary outcomes were the Clinician Administered PTSD Scale (CAPS), the PTSD Symptom Scale-Self Report (PSS-SR), and a substance use inventory (self-reported abstinence and percentage of days of use over 7 days). Intention-to-treat analysis showed large, clinically significant reductions in CAPS and PSS-SR symptoms (d = 1.94 and 1.12, respectively) but no reliable difference between conditions. Substance use outcomes were not significantly different over time between the two treatments and at follow-up showed no significant change from baseline. Study results do not favor Seeking Safety over WHE as an adjunct to substance use disorder treatment for women with PTSD and reflect considerable opportunity to improve clinical outcomes in community-based treatments for these co-occurring conditions.

Pubmed ID: 19634955 RIS Download

Mesh terms: Adolescent | Adult | Aged | Cognitive Therapy | Comorbidity | Female | Follow-Up Studies | Health Education | Humans | Middle Aged | Personality Inventory | Psychotherapy, Group | Stress Disorders, Post-Traumatic | Substance-Related Disorders | Treatment Outcome | United States | Young Adult

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Associated grants

  • Agency: NIDA NIH HHS, Id: K24 DA022412
  • Agency: NIDA NIH HHS, Id: U10 DA013035
  • Agency: NIDA NIH HHS, Id: U10 DA013035-02
  • Agency: NIDA NIH HHS, Id: U10 DA013035-02S1
  • Agency: NIDA NIH HHS, Id: U10 DA013035-03
  • Agency: NIDA NIH HHS, Id: U10 DA013035-03S1
  • Agency: NIDA NIH HHS, Id: U10 DA013035-04
  • Agency: NIDA NIH HHS, Id: U10 DA013035-04S1
  • Agency: NIDA NIH HHS, Id: U10 DA013035-05
  • Agency: NIDA NIH HHS, Id: U10 DA013035-05S1
  • Agency: NIDA NIH HHS, Id: U10 DA013035-05S2
  • Agency: NIDA NIH HHS, Id: U10 DA013035-05S3
  • Agency: NIDA NIH HHS, Id: U10 DA013035-05S4
  • Agency: NIDA NIH HHS, Id: U10 DA013035-06
  • Agency: NIDA NIH HHS, Id: U10 DA013035-06S1
  • Agency: NIDA NIH HHS, Id: U10 DA013035-07
  • Agency: NIDA NIH HHS, Id: U10 DA013035-07S1
  • Agency: NIDA NIH HHS, Id: U10 DA013035-08
  • Agency: NIDA NIH HHS, Id: U10 DA013035-08S1
  • Agency: NIDA NIH HHS, Id: U10 DA013035-08S2
  • Agency: NIDA NIH HHS, Id: U10 DA013046
  • Agency: NIDA NIH HHS, Id: U10 DA013714
  • Agency: NIDA NIH HHS, Id: U10 DA013720
  • Agency: NIDA NIH HHS, Id: U10 DA013727
  • Agency: NIDA NIH HHS, Id: U10 DA13035
  • Agency: NIDA NIH HHS, Id: U10 DA13038
  • Agency: NIDA NIH HHS, Id: U10 DA13714
  • Agency: NIDA NIH HHS, Id: U10 DA13727
  • Agency: NIDA NIH HHS, Id: U10 DA13732

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