We have updated our privacy policy. If you have any question, contact us at privacy@scicrunch.org. Dismiss and don't show again

Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Selective expansion of the monocytic lineage directed by bacterial infection.

CCR2-mediated recruitment of Ly6C(high) monocytes is essential for defense against a range of microbial pathogens. Although our understanding of monocyte trafficking to inflammatory sites is increasing, how innate immune inflammation influences monocyte development and maturation during microbial infection remains undefined. Herein, we demonstrate that infection with the intracellular bacterial pathogen Listeria monocytogenes specifically and selectively promotes monopoiesis. Systemic infection with virulent L. monocytogenes induces marked proliferation of bone marrow monocyte precursors and results in depletion of myeloid progenitors. Proliferation of monocyte precursors correlates with the intensity of systemic infection and is unaffected by the density of monocytes in the bone marrow. Although MyD88/Trif-mediated signaling is not required for early emigration of the mature monocyte population from the bone marrow, replenishment of monocyte populations depends on MyD88/Trif. Our studies demonstrate that TLR-mediated signals play an essential role in the maintenance of monocyte homeostasis during systemic bacterial infection.

Pubmed ID: 19596996 RIS Download

Mesh terms: Adaptor Proteins, Vesicular Transport | Animals | Bacterial Infections | Bone Marrow Cells | Cell Lineage | Cell Proliferation | Chemotaxis, Leukocyte | Homeostasis | Listeria monocytogenes | Listeriosis | Mice | Mice, Knockout | Monocyte-Macrophage Precursor Cells | Monocytes | Myeloid Differentiation Factor 88 | Toll-Like Receptors

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

Associated grants

  • Agency: NCI NIH HHS, Id: K12 CA120121
  • Agency: NIAID NIH HHS, Id: R37 AI039031-14
  • Agency: NCI NIH HHS, Id: P01 CA023766
  • Agency: NIAID NIH HHS, Id: R01 AI080619
  • Agency: NCI NIH HHS, Id: P01 CA023766-310044
  • Agency: NCI NIH HHS, Id: P01 CA023766-30
  • Agency: NIAID NIH HHS, Id: R37 AI039031
  • Agency: NIAID NIH HHS, Id: K08AI071998
  • Agency: NIAID NIH HHS, Id: K08 AI071998
  • Agency: NIAID NIH HHS, Id: R37AI39031

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.