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The Gene Ontology's Reference Genome Project: a unified framework for functional annotation across species.

The Gene Ontology (GO) is a collaborative effort that provides structured vocabularies for annotating the molecular function, biological role, and cellular location of gene products in a highly systematic way and in a species-neutral manner with the aim of unifying the representation of gene function across different organisms. Each contributing member of the GO Consortium independently associates GO terms to gene products from the organism(s) they are annotating. Here we introduce the Reference Genome project, which brings together those independent efforts into a unified framework based on the evolutionary relationships between genes in these different organisms. The Reference Genome project has two primary goals: to increase the depth and breadth of annotations for genes in each of the organisms in the project, and to create data sets and tools that enable other genome annotation efforts to infer GO annotations for homologous genes in their organisms. In addition, the project has several important incidental benefits, such as increasing annotation consistency across genome databases, and providing important improvements to the GO's logical structure and biological content.

Pubmed ID: 19578431 RIS Download

Mesh terms: Animals | Cluster Analysis | Database Management Systems | Databases, Genetic | Genomics | Humans | Vocabulary, Controlled

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Associated grants

  • Agency: NHGRI NIH HHS, Id: U41 HG001315
  • Agency: NHGRI NIH HHS, Id: P41 HG002659
  • Agency: NIGMS NIH HHS, Id: U24 GM088849
  • Agency: NHLBI NIH HHS, Id: R01 HL064541
  • Agency: NHGRI NIH HHS, Id: U41 HG002273
  • Agency: NHLBI NIH HHS, Id: HL64541
  • Agency: NHGRI NIH HHS, Id: P41 HG000330
  • Agency: NHGRI NIH HHS, Id: P41 HG001315
  • Agency: NHGRI NIH HHS, Id: P41 HG002223
  • Agency: NICHD NIH HHS, Id: R01 HD033745
  • Agency: NHGRI NIH HHS, Id: U41 HG002223
  • Agency: NHGRI NIH HHS, Id: P41 HG002659-06
  • Agency: NHGRI NIH HHS, Id: U41 HG002659
  • Agency: NIGMS NIH HHS, Id: U24 GM07790
  • Agency: NHGRI NIH HHS, Id: P41 HG02223
  • Agency: British Heart Foundation, Id: SP/07/007/23671
  • Agency: Medical Research Council, Id: G0500293
  • Agency: NHGRI NIH HHS, Id: R01 HG002273
  • Agency: NIGMS NIH HHS, Id: T32 GM007790
  • Agency: NIGMS NIH HHS, Id: R01 GM064426
  • Agency: NICHD NIH HHS, Id: HD033745
  • Agency: NHGRI NIH HHS, Id: HG00022
  • Agency: NIGMS NIH HHS, Id: GM64426
  • Agency: NHGRI NIH HHS, Id: P41 HG002273

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